New Strategy for Controlled Release of Nitric Oxide

New Strategy for Controlled Release of Nitric Oxide

Author Seabra, Amedea B. Autor UNIFESP Google Scholar
Marcato, Priscyla D. Google Scholar
Paula, Larissa B. de Google Scholar
Duran, Nelson Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Campinas (UNICAMP)
Universidade Federal do ABC (UFABC)
Abstract Nitric oxide (NO) is involved in several physiological processes, such as the control of vascular tone, the inhibition of platelet aggregation, smooth muscle cell replication, immune response and neuronal communication. Several pathologies have been associated to dysfunctions in the endogenous NO production. Thus, there is a great interest in the development of NO-releasing drugs and in matrices which are able to stabilize and release NO locally in different tissues. in this scenario, the preparation of NO-releasing nanomaterials, such as dendrimers, liposomes, metallic, silica, and polymeric nanoparticles, zeolites and metal organic frameworks, is a promising strategy for delivering NO in diverse applications, as discussed in this work.
Keywords Nitric Oxide
Nanoparticles
Controlled Release
Wound Healing
polymers
S-nitrosothiols
Language English
Date 2012-01-01
Published in Journal of Nano Research. Stafa-zuerich: Trans Tech Publications Ltd, v. 20, p. 61-67, 2012.
ISSN 1662-5250 (Sherpa/Romeo, impact factor)
Publisher Trans Tech Publications Ltd
Extent 61-67
Origin http://dx.doi.org/10.4028/www.scientific.net/JNanoR.20.61
Access rights Closed access
Type Article
Web of Science ID WOS:000313760400007
URI http://repositorio.unifesp.br/handle/11600/34519

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