Strategies for the Treatment of Antipsychotic-Induced Sexual Dysfunction and/or Hyperprolactinemia Among Patients of the Schizophrenia Spectrum: A Review
Nunes, Luciana Vargas Alves [UNIFESP]
Moreira, Hugo Cogo [UNIFESP]
Razzouk, Denise [UNIFESP]
Nunes, Sandra Odebrecht Vargas
Mari, Jair de Jesus [UNIFESP]
Is part ofJournal of Sex & Marital Therapy
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There is limited evidence for the management of sexual dysfunction and/or hyperprolactinemia resulting from use of antipsychotics in patients with schizophrenia and spectrum. the aim of this study was to review and describe the strategies for the treatment of antipsychotic-induced sexual dysfunctions and/or hyperprolactinemia. the research was carried out through Medline/PubMed, Cochrane, Lilacs, Embase, and PsycINFO, and it included open labels or randomized clinical trials. the authors found 31 studies: 25 open-label noncontrolled studies and 6 randomized controlled clinical trials. the randomized, double-blind controlled studies that were conducted with adjunctive treatment that showed improvement of sexual dysfunction and/or decrease of prolactin levels were sildenafil and aripiprazole. the medication selegiline and cyproheptadine did not improve sexual function. the switch to quetiapine was demonstrated in 2 randomized controlled studies: 1 showed improvement in the primary outcome and the other did not. This reviewed data have suggested that further well-designed randomized controlled trials are needed to provide evidence for the effects of different strategies to manage sexual dysfunction and/or hyperprolactinaemia resulting from antipsychotics. These trials are necessary in order to have a better compliance and reduce the distress among patients with schizophrenia.
CitationJournal of Sex & Marital Therapy. Abingdon: Routledge Journals, Taylor & Francis Ltd, v. 38, n. 3, p. 281-301, 2012.
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