Electrical signaling in control of ocular cell behaviors

Electrical signaling in control of ocular cell behaviors

Author Zhao, Min Google Scholar
Chalmers, Laura Google Scholar
Cao, Lin Google Scholar
Vieira, Ana C. Autor UNIFESP Google Scholar
Mannis, Mark Google Scholar
Reid, Brian Google Scholar
Institution Univ Calif Davis
Universidade Federal de São Paulo (UNIFESP)
Abstract Epithelia of the cornea, lens and retina contain a vast array of ion channels and pumps. Together they produce a polarized flow of ions in and out of cells, as well as across the epithelia. These naturally occurring ion fluxes are essential to the hydration and metabolism of the ocular tissues, especially for the avascular cornea and lens. the directional transport of ions generates electric fields and currents in those tissues. Applied electric fields affect migration, division and proliferation of ocular cells which are important in homeostasis and healing of the ocular tissues. Abnormalities in any of those aspects may underlie many ocular diseases, for example chronic corneal ulcers, posterior capsule opacity after cataract surgery, and retinopathies. Electric field-inducing cellular responses, termed electrical signaling here, therefore may be an unexpected yet powerful mechanism in regulating ocular cell behavior. Both endogenous electric fields and applied electric fields could be exploited to regulate ocular cells. We aim to briefly describe the physiology of the naturally occurring electrical activities in the corneal, lens, and retinal epithelia, to provide experimental evidence of the effects of electric fields on ocular cell behaviors, and to suggest possible clinical implications. (C) 2011 Elsevier B.V. All rights reserved.
Keywords Ion flux
Electric field
Cell migration
Cell proliferation
Wound healing
Electrotaxis/galvanotaxis
Language English
Sponsor NIH
Wellcome Trust
UC Davis
California Institute of Regenerative Medicine
NSF
Research to Prevent Blindness, Inc.
Grant number NIH: 1R01EY019101
Wellcome Trust: 068012
California Institute of Regenerative Medicine: RB1-01417
NSF: MCB-0951199
Date 2012-01-01
Published in Progress in Retinal and Eye Research. Oxford: Pergamon-Elsevier B.V., v. 31, n. 1, p. 65-88, 2012.
ISSN 1350-9462 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 65-88
Origin http://dx.doi.org/10.1016/j.preteyeres.2011.10.001
Access rights Closed access
Type Article
Web of Science ID WOS:000301217800004
URI http://repositorio.unifesp.br/handle/11600/34461

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