Electroacupuncture and Moxibustion Decrease Renal Sympathetic Nerve Activity and Retard Progression of Renal Disease in Rats
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2012-01-01
Autores
Paterno, Josne Carla [UNIFESP]
Bergamaschi, Cassia Toledo [UNIFESP]
Campos, Ruy Ribeiro [UNIFESP]
Higa, Elisa Mieko Suemitsu [UNIFESP]
Soares, Maria Fernanda Sanches [UNIFESP]
Schor, Nestor [UNIFESP]
Freire, Anaflavia de Oliveira [UNIFESP]
Teixeira, Vicente de Paulo Castro [UNIFESP]
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Background/Aim: Chronic kidney disease (CKD) is an increasing major public health problem worldwide. the sympathetic nervous system and nitric oxide play an important role in the pathogenesis of CKD. Traditional Chinese medicine has accumulated thousands of years of therapeutic experiences. Electroacupuncture (EA) and moxibustion (MO) are two such therapeutic strategies. the aim of this study was to investigate the renal and hemodynamic effects of EA-MO in an experimental model of a CKD. Methods: Male Wistar rats submitted to 5/6th nephrectomy (5/6 NX) were studied for 8 weeks. There were four groups: (1) control, normal rats; (2) NX, 5/6 NX only; (3) NX-AS, 5/6 NX and EA-MO session using sham points, and (4) NX-AM, 5/6 NX and EA-MO session using real acupoints. Biochemical and blood pressure studies, renal sympathetic nerve activity measurements, nitric oxide levels and the histopathological indices were assessed. Results:The EA- and MO-treated group presented significant improvement in all measured functional and histopathological parameters. Conclusion: These findings suggest that EA-MO had beneficial effects on CKD. This effect was probably achieved by the modulation of the renal sympathetic nerve activity and nitric oxide levels, leading to decreased blood pressure, which is associated with less proteinuria. Copyright (c) 2012 S. Karger AG, Basel
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Kidney & Blood Pressure Research. Basel: Karger, v. 35, n. 5, p. 355-364, 2012.