Electroacupuncture and Moxibustion Decrease Renal Sympathetic Nerve Activity and Retard Progression of Renal Disease in Rats

Electroacupuncture and Moxibustion Decrease Renal Sympathetic Nerve Activity and Retard Progression of Renal Disease in Rats

Author Paterno, Josne Carla Autor UNIFESP Google Scholar
Bergamaschi, Cassia Toledo Autor UNIFESP Google Scholar
Campos, Ruy Ribeiro Autor UNIFESP Google Scholar
Higa, Elisa Mieko Suemitsu Autor UNIFESP Google Scholar
Soares, Maria Fernanda Sanches Autor UNIFESP Google Scholar
Schor, Nestor Autor UNIFESP Google Scholar
Freire, Anaflavia de Oliveira Autor UNIFESP Google Scholar
Teixeira, Vicente de Paulo Castro Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background/Aim: Chronic kidney disease (CKD) is an increasing major public health problem worldwide. the sympathetic nervous system and nitric oxide play an important role in the pathogenesis of CKD. Traditional Chinese medicine has accumulated thousands of years of therapeutic experiences. Electroacupuncture (EA) and moxibustion (MO) are two such therapeutic strategies. the aim of this study was to investigate the renal and hemodynamic effects of EA-MO in an experimental model of a CKD. Methods: Male Wistar rats submitted to 5/6th nephrectomy (5/6 NX) were studied for 8 weeks. There were four groups: (1) control, normal rats; (2) NX, 5/6 NX only; (3) NX-AS, 5/6 NX and EA-MO session using sham points, and (4) NX-AM, 5/6 NX and EA-MO session using real acupoints. Biochemical and blood pressure studies, renal sympathetic nerve activity measurements, nitric oxide levels and the histopathological indices were assessed. Results:The EA- and MO-treated group presented significant improvement in all measured functional and histopathological parameters. Conclusion: These findings suggest that EA-MO had beneficial effects on CKD. This effect was probably achieved by the modulation of the renal sympathetic nerve activity and nitric oxide levels, leading to decreased blood pressure, which is associated with less proteinuria. Copyright (c) 2012 S. Karger AG, Basel
Keywords Chronic kidney disease
Nitric oxide
Renal sympathetic nerve activity
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2012-01-01
Published in Kidney & Blood Pressure Research. Basel: Karger, v. 35, n. 5, p. 355-364, 2012.
ISSN 1420-4096 (Sherpa/Romeo, impact factor)
Publisher Karger
Extent 355-364
Origin http://dx.doi.org/10.1159/000336095
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000305594600008
URI http://repositorio.unifesp.br/handle/11600/34383

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