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dc.contributor.authorNoto, Cristiano Souza [UNIFESP]
dc.contributor.authorGadelha, Ary [UNIFESP]
dc.contributor.authorBelangero, Sintia Iole [UNIFESP]
dc.contributor.authorSmith, Marilia de Arruda Cardoso [UNIFESP]
dc.contributor.authorAguiar, Bianca Wollenhaupt de
dc.contributor.authorPanizzuti, Bruna
dc.contributor.authorMari, Jair de Jesus [UNIFESP]
dc.contributor.authorGama, Clarissa Severino
dc.contributor.authorBressan, Rodrigo Affonseca [UNIFESP]
dc.contributor.authorBrietzke, Elisa [UNIFESP]
dc.date.accessioned2016-01-24T14:17:27Z
dc.date.available2016-01-24T14:17:27Z
dc.date.issued2011-11-21
dc.identifierhttp://dx.doi.org/10.1016/j.neulet.2011.10.042
dc.identifier.citationNeuroscience Letters. Clare: Elsevier B.V., v. 505, n. 3, p. 282-285, 2011.
dc.identifier.issn0304-3940
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34232
dc.description.abstractEmergence of depressive symptoms in schizophrenia results in a deteriorating course and poor prognosis. Schizophrenia and depressive disorder are both associated with low levels of brain-derived neurotrophic factor (BDNF) and with a longstanding low grade inflammatory state. the objective of this study is to analyze the relationship between these serum biomarkers and depressive and psychotic symptoms in schizophrenic patients. Thirty-nine individuals diagnosed with schizophrenia or schizoaffective disorder by Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), assessed by Structured Clinical Interview for DSM-IV (SCID), were included. Interviews were conducted with the Positive and Negative Syndrome Scale (PANSS) and the Calgary Depression Scale for Schizophrenia (CDSS). Blood samples were collected for determination of BDNF, IL-1 beta, IL-6, IL-8,1-10, IL-12 and TNF-alpha measurements. Positive correlations between BDNF and CDSS and between IL-1beta and severity in PANSS scores were found. BDNF levels were not correlated with any cytokine or with PANSS scores. the results of this study suggest that depressive and psychotic symptoms may be associated with different profiles of biomarkers in the association between schizophrenia and depression. (C) 2011 Elsevier Ireland Ltd. All rights reserved.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFAPERGS
dc.format.extent282-285
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience Letters
dc.rightsAcesso aberto
dc.subjectSchizophreniaen
dc.subjectBiomarkersen
dc.subjectDepressive symptomsen
dc.subjectBrain-derived neurotrophic factoren
dc.subjectCytokinesen
dc.titleAssociation of biomarkers and depressive symptoms in schizophreniaen
dc.typeArtigo
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Fed Rio Grande do Sul
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychiat, Program Schizophrenia, BR-04044000 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychiat, Program Recognit & Intervent Individuals Risk Men, BR-04044000 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Program Postgrad Psychiat, BR-04044000 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Morphol & Genet, BR-04044000 São Paulo, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Lab Mol Psychiat, Porto Alegre, RS, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Hosp Clin Porto Alegre, INCT Translat Med, Porto Alegre, RS, Brazil
dc.description.affiliationUniv Fed Rio Grande do Sul, Program Postgrad Med Psychiat, Porto Alegre, RS, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychiat, Program Schizophrenia, BR-04044000 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychiat, Program Recognit & Intervent Individuals Risk Men, BR-04044000 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Program Postgrad Psychiat, BR-04044000 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Morphol & Genet, BR-04044000 São Paulo, Brazil
dc.description.sponsorshipIDCNPq: Universal 477974/2009-0
dc.description.sponsorshipIDCNPq: PQ 305967/2008-8
dc.description.sponsorshipIDFAPERGS: PqG 1009340 - 06/2010
dc.description.sponsorshipIDCNPq: PRONEM 11/2057-2
dc.identifier.fileWOS000298465500014.pdf
dc.identifier.doi10.1016/j.neulet.2011.10.042
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000298465500014


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