Novel etiopathophysiological aspects of thyrotoxic periodic paralysis

Show simple item record

dc.contributor.author Maciel, Rui M. B. [UNIFESP]
dc.contributor.author Lindsey, Susan C. [UNIFESP]
dc.contributor.author Dias da Silva, Magnus R. [UNIFESP]
dc.date.accessioned 2016-01-24T14:17:25Z
dc.date.available 2016-01-24T14:17:25Z
dc.date.issued 2011-11-01
dc.identifier http://dx.doi.org/10.1038/nrendo.2011.58
dc.identifier.citation Nature Reviews Endocrinology. New York: Nature Publishing Group, v. 7, n. 11, p. 657-667, 2011.
dc.identifier.issn 1759-5029
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/34205
dc.description.abstract Thyrotoxicosis can lead to thyrotoxic periodic paralysis (TPP), an endocrine channelopathy, and is the most common cause of acquired periodic paralysis. Typically, paralytic attacks cease when hyperthyroidism is abolished, and recur if hyperthyroidism returns. TPP is often underdiagnosed, as it has diverse periodicity, duration and intensity. the age at which patients develop TPP closely follows the age at which thyrotoxicosis occurs. All ethnicities can be affected, but TPP is most prevalent in people of Asian and, secondly, Latin American descent. TPP is characterized by hypokalemia, suppressed TSH levels and increased levels of thyroid hormones. Nonselective beta adrenergic blockers, such as propranolol, are an efficient adjuvant to antithyroid drugs to prevent paralysis; however, an early and definitive treatment should always be pursued. Evidence indicates that TPP results from the combination of genetic susceptibility, thyrotoxicosis and environmental factors (such as a high-carbohydrate diet). We believe that excess T-3 modifies the insulin sensitivity of skeletal muscle and pancreatic beta cells and thus alters potassium homeostasis, but only leads to a depolarization-induced acute loss of muscle excitability in patients with inherited ion channel mutations. An integrated etiopathophysiological model is proposed based on molecular findings and knowledge gained from long-term follow-up of patients with TPP. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Fleury Group
dc.format.extent 657-667
dc.language.iso eng
dc.publisher Nature Publishing Group
dc.relation.ispartof Nature Reviews Endocrinology
dc.rights Acesso restrito
dc.title Novel etiopathophysiological aspects of thyrotoxic periodic paralysis en
dc.type Resenha
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Biochem, BR-04039032 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Escola Paulista Med, Dept Med, Lab Mol & Translat Endocrinol, BR-04039032 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Biochem, BR-04039032 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Escola Paulista Med, Dept Med, Lab Mol & Translat Endocrinol, BR-04039032 São Paulo, Brazil
dc.identifier.doi 10.1038/nrendo.2011.58
dc.description.source Web of Science
dc.identifier.wos WOS:000296565200007



File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account