Tobacco use and dementia: evidence from the 1066 dementia population-based surveys in Latin America, China and India

Tobacco use and dementia: evidence from the 1066 dementia population-based surveys in Latin America, China and India

Author Ferri, Cleusa P. Google Scholar
West, Robert Google Scholar
Moriyama, Tais S. Autor UNIFESP Google Scholar
Acosta, Daisy Google Scholar
Guerra, Mariella Google Scholar
Huang, Yueqin Google Scholar
Jacob, K. S. Google Scholar
Ribeiro, Wagner Autor UNIFESP Google Scholar
Llibre de Rodriguez, Juan J. Google Scholar
Salas, Aquiles Google Scholar
Luisa Sosa, Ana Google Scholar
Williams, Joseph Google Scholar
Acosta, Isaac Google Scholar
Liu, Zhaouri Google Scholar
Guerra Hernandez, Milagros A. Google Scholar
Prince, Martin J. Google Scholar
Institution Kings Coll London
UCL
Universidade Federal de São Paulo (UNIFESP)
Univ Nacl Pedro Henriquez Urena
Univ Peruana Cayetano Heredia
Peking Univ
Christian Med Coll & Hosp
Med Univ Havana
Caracas Univ Hosp
Natl Inst Neurol & Neurosurg Mexico
VHS
Policlin Univ 27 Noviembre
Abstract Objectives: To assess the association between tobacco consumption and dementia using the same methodology in seven developing countries, testing the specific hypotheses that higher exposure to tobacco is associated with a higher prevalence of dementia, that the association is limited to smoked tobacco and is stronger for vascular dementia compared to Alzheimer's disease.Methods: Cross-sectional surveys conducted on individuals aged 65+. A total of 15 022 residents in specified catchment areas were assessed face-to-face using a standardised protocol, which included dementia diagnosis and detailed information on past and current tobacco consumption, and on important potential confounders of this association.Results: A high proportion of participants were never smokers (52% in Dominican Republic to 83% in Peru), most of those who ever used tobacco in China and India were still smoking at age 65 and above (80% and 84%, respectively). There was a positive association between history of tobacco smoke exposure (pack years up to age 50) and dementia (pooled PR = 1.003; 95% CI 1.001-1.005), Alzheimer's disease (pooled PR = 1.007; 95% CI, 1.003-1.011) and Vascular Dementia (pooled PR = 1.003; 95% CI = 1.001-1.005). These associations were attenuated but remained significant if exposure after the age of 50 was included. in India there was no association between smokeless tobacco and dementia.Conclusions: Dementia in developing countries appears to be positively associated with history of tobacco smoking but not smokeless tobacco use. Selective quitting in later life may bias estimation of associations. Copyright (C) 2011 John Wiley & Sons, Ltd.
Keywords dementia
Alzheimer's disease
vascular dementia
tobacco
developing countries
Language English
Sponsor WellcomeTrust
Rock-efeller Foundation
World Health Organisation (India)
World Health Organisation (Dominican Republic)
World Health Organisation (China)
US Alzheimer's Association (Peru)
US Alzheimer's Association (Mexico)
US Alzheimer's Association (Argentina)
FONACIT/CDCH/UCV (Venezuela)
Date 2011-11-01
Published in International Journal of Geriatric Psychiatry. Malden: Wiley-Blackwell, v. 26, n. 11, p. 1177-1185, 2011.
ISSN 0885-6230 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 1177-1185
Origin http://dx.doi.org/10.1002/gps.2661
Access rights Closed access
Type Article
Web of Science ID WOS:000296447300010
URI http://repositorio.unifesp.br/handle/11600/34177

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