Are adverse effects of antiepileptic drugs different in symptomatic partial and idiopathic generalized epilepsies? the Portuguese-Brazilian validation of the Liverpool Adverse Events Profile

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Date
2011-11-01Author
Martins, Heloise Helena [UNIFESP]
Alonso, Neide Barreira [UNIFESP]
Vidal-Dourado, Marcos [UNIFESP]
Carbonel, Thiago Delfino [UNIFESP]
Araujo Filho, Gerardo Maria de [UNIFESP]
Caboclo, Luís Otávio Sales Ferreira [UNIFESP]
Yacubian, Elza Márcia Targas [UNIFESP]
Guilhoto, Laura Maria de Figueiredo Ferreira [UNIFESP]
Type
ArtigoISSN
1525-5050Is part of
Epilepsy & BehaviorDOI
10.1016/j.yebeh.2011.08.005Metadata
Show full item recordAbstract
We report the results of administration of the Portuguese-Brazilian translation of the Liverpool Adverse Events Profile (LAEP) to 100 patients (mean age = 34.5, SD = 12.12; 56 females), 61 with symptomatic partial epilepsy (SPE) and 39 with idiopathic generalized epilepsy (ICE) (ILAE, 1989) who were on a stable antiepileptic drug (AED) regimen and being treated in a Brazilian tertiary epilepsy center. Carbamazepine was the most commonly used AED (43.0%), followed by valproic acid (32.0%). Two or more AEDs were used by 69.0% of patients. the mean LAEP score (19 questions) was 37.6 (SD = 13.35). the most common adverse effects were sleepiness (35.0%), memory problems (35.0%), and difficulty in concentrating (25.0%). Higher LAEP scores were associated with polytherapy with three or more AEDs (P=0.005), female gender (P<0.001), older age (P<0.001), and uncontrolled seizures (P = 0.045). the intraclass coefficient (test-retest reliability) for LAEP overall score was 0.848 (95% CI = 0.782-0.895), with a range from 0.370 (unsteadiness) to 0.750 (memory problems). Cronbach's alpha coefficient (internal consistency) was 0.903. the LAEP was highly correlated with Quality of Life in Epilepsy-31 inventory (r = -0.804, P>0.001) and Hospital Anxiety and Depression Scale (Depression: r = 0.637, P<0.001; Anxiety: r = 0.621, P<0.001) dimensions. LAEP overall scores were similar in people with SPE and IGE and were not helpful in differentiating adverse effects in these two groups. Clinical variables that influenced global LAEP were seizure frequency (P = 0.050) and generalized tonic-clonic seizures in the last month (P = 0.031) in the ICE group, and polytherapy with three or more AEDs (P = 0.003 and P = 0.003) in both ICE and SPE groups. (C) 2011 Elsevier Inc. All rights reserved.
Citation
Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 22, n. 3, p. 511-517, 2011.Keywords
Liverpool Adverse Events ProfileAntiepileptic drugs
Epilepsy
Adverse effects
Symptomatic partial epilepsy
Idiopathic generalized epilepsy
Validation
Sponsorship
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Collections
- EPM - Artigos [17701]
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