Nandrolone and resistance training induce heart remodeling: Role of fetal genes and implications for cardiac pathophysiology

Nandrolone and resistance training induce heart remodeling: Role of fetal genes and implications for cardiac pathophysiology

Author Tanno, Ana Paula Google Scholar
Neves, Vander José das Google Scholar
Rosa, Kaleizu Teodoro Google Scholar
Cunha, Tatiana Sousa Autor UNIFESP Google Scholar
Linarello Giordano, Fernanda Cristina Google Scholar
Calil, Caroline Morini Google Scholar
Guzzoni, Vinicius Google Scholar
Fernandes, Tiago Google Scholar
Oliveira, Edilamar Menezes de Google Scholar
Novaes, Pedro Duarte Google Scholar
Irigoyen, Maria Claudia Autor UNIFESP Google Scholar
Moura, Maria José Costa Sampaio Google Scholar
Marcondes, Fernanda Klein Google Scholar
Institution Universidade Estadual de Campinas (UNICAMP)
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Aims: This study was conducted to assess the isolated and combined effects of nandrolone and resistance training on cardiac morphology, function, and mRNA expression of pathological cardiac hypertrophy markers.Main methods: Wistar rats were randomly divided into four groups and submitted to 6 weeks of treatment with nandrolone and/or resistance training. Cardiac parameters were determined by echocardiography. Heart was analyzed for collagen infiltration. Real-time RT-PCR was used to assess the pathological cardiac hypertrophy markers.Key findings: Both resistance training and nandrolone induced cardiac hypertrophy. Nandrolone increased the cardiac collagen content, and reduced the cardiac index in non-trained and trained groups, when compared with the respective vehicle-treated groups. Nandrolone reduced the ratio of maximum early to late transmitral flow velocity in non-trained and trained groups, when compared with the respective vehicle-treated groups. Nandrolone reduced the alpha-myosin heavy chain gene expression in both non-trained and trained groups, when compared with the respective vehicle-treated groups. Training reduced the beta-myosin heavy chain gene expression in the groups treated with vehicle and nandrolone. Only the association between training and nandrolone increased the expression of the skeletal alpha-actin gene and atrial natriuretic peptide in the left ventricle.Significance: This study indicated that nandrolone, whether associated with resistance training or not, induces cardiac hypertrophy, which is associated with enhanced collagen content, re-expression of fetal genes the in left ventricle, and impaired diastolic and systolic function. (C) 2011 Elsevier Inc. All rights reserved.
Keywords Cardiac hypertrophy
Genes
Training
Collagen
Echocardiography
Nandrolone
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
FAEPEX/UNICAMP
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 05/60284-6
Date 2011-10-24
Published in Life Sciences. Oxford: Pergamon-Elsevier B.V., v. 89, n. 17-18, p. 631-637, 2011.
ISSN 0024-3205 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 631-637
Origin http://dx.doi.org/10.1016/j.lfs.2011.08.004
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000295904100006
URI http://repositorio.unifesp.br/handle/11600/34152

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