Psychosis during peginterferon-alpha2a and ribavirin therapy: case report

Psychosis during peginterferon-alpha2a and ribavirin therapy: case report

Author Quarantini, Lucas de Castro Autor UNIFESP Google Scholar
Cruz, Simone Cunha Google Scholar
Batista-Neves, Susana Carolina Google Scholar
Paraná, Raymundo Google Scholar
Miranda-Scippa, Ângela Marisa de Aquino Autor UNIFESP Google Scholar
Bressan, Rodrigo Affonseca Autor UNIFESP Google Scholar
Institution Federal University of Bahia Neuropsychiatry Department
Federal University of Bahia Gastroenterology
Universidade Federal de São Paulo (UNIFESP)
Abstract Pegylated Interferon-alpha, combined with ribavirin, gives high sustained virological response in patients with hepatitis C virus, an important public health problem and one of the most frequent chronic infectious diseases worldwide. Though it has therapeutic benefits, treatment with IFN-alpha may be complicated by various side effects, especially symptoms of major depression and acute mania. Psychosis is a rare side effect, and its management usually includes discontinuation of IFN-alpha. We report a case of psychotic disorder that occurred during therapy with pegylated Interferon-alpha given associated with ribavirin. After good response to psychiatric treatment, it became possible to finish the anti-viral therapy.
Keywords Interferon-alpha
hepatitis C
Language English
Date 2006-12-01
Published in Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 10, n. 6, p. 406-407, 2006.
ISSN 1413-8670 (Sherpa/Romeo)
Publisher Brazilian Society of Infectious Diseases
Extent 406-407
Access rights Open access Open Access
Type Article
SciELO ID S1413-86702006000600010 (statistics in SciELO)

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