Increased basal plasma brain-derived neurotrophic factor levels in sprint runners

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2011-10-01
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Correia, Paulo Roberto [UNIFESP]
Scorza, Fulvio Alexandre [UNIFESP]
Silva, Sergio Gomes da [UNIFESP]
Pansani, Aline [UNIFESP]
Toscano-Silva, Michelle [UNIFESP]
Almeida, Antonio Carlos de
Arida, Ricardo Mario [UNIFESP]
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Objective Exercise is known to enhance circulating brain-derived neurotrophic factor (BDNF) levels in healthy humans. BDNF changes have been measured in endurance but not in strength exercise. the present study aimed to investigate whether anaerobic activity such as sprinting differentially alters basal plasma BDNF concentration. Methods Brazilian sprinters (100 m) at either the international (Olympics and Outdoor World Championships) (n = 14) or the domestic level (n = 8), and sedentary subjects (n = 15), were recruited. Plasma BDNF concentrations were analyzed by enzyme-linked immunosorbent assay. Results the basal plasma BDNF concentrations were significantly higher in the international and the domestic sprinters than in the sedentary subjects. in addition, sprinters at the international level had higher plasma BDNF concentrations than those at the domestic level. Conclusion Our findings suggest that increased basal plasma BDNF level is related to enhanced exercise performance.
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Neuroscience Bulletin. New York: Springer, v. 27, n. 5, p. 325-329, 2011.
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