Acute Hepatitis C in Brazil: Results of a National Survey

Acute Hepatitis C in Brazil: Results of a National Survey

Author Paiva Ferreira, Adalgisa de Souza Google Scholar
Perez, Renata de Mello Google Scholar
Gomes Ferraz, Maria Lucia Autor UNIFESP Google Scholar
Lewis-Ximenez, Lia Laura Google Scholar
Pereira, Joao Luis Google Scholar
Lerias de Almeida, Paulo Roberto Google Scholar
Mattos, Angelo Alves de Google Scholar
Acute Hepatitis C Study Grp Brazil Google Scholar
Institution Univ Fed Maranhao
Universidade Federal do Rio de Janeiro (UFRJ)
Universidade Federal de São Paulo (UNIFESP)
Osvaldo Cruz Fdn
Gen Hosp Bonsucesso
Nossa Senhora Conceicao Hosp
Fed Fdn Sch Med Sci
Abstract The incidence of acute hepatitis C has decreased in the world. However, new cases are still reported. the objective of this study was to obtain data of acute hepatitis C in Brazil and to identify risk factors of transmission, diagnostic criteria, clinical presentation, evolution, and treatment. A questionnaire was sent to all members of the Brazilian Society of Hepatology. Sixteen centers participated with a total of 170 cases between 2000 and 2008. Among them, 37 had chronic renal failure on hemodialysis and were evaluated separately. the main diagnostic criterion in non-uremic patients was ALT (alanine aminotransferase) elevation associated with risk factors. in patients with chronic renal failure, anti-hepatitis C virus (HCV) sero-conversion was the most frequent criterion. Among the 133 non-uremic patients the main risk factors were hospital procedures, whereas in hemodialysis patients, dialysis was the single risk factor in 95% of the cases. Jaundice was more frequent in non-uremic patients (82% vs. 13%; P < 0.001) and ALT levels were higher in these individuals (P < 0.001). Spontaneous clearance was more frequent in non-uremic patients (51% vs. 3%; P < 0.001). Sixty-five patients were treated: 39 non-urennic patients and 26 on dialysis. Sustained virological response rates were 60% for non-uremic and 58% for uremic patients (P = 0.98). There was no association of these rates with the study variables. These findings show that cases of acute hepatitis C are still occurring and have been related predominantly to hospital procedures. Measures to prevent nosocomial transmission should be adopted rigorously and followed to minimize this important source of infection observed in this survey. J. Med. Virol. 83:1738-1743, 2011. (C) 2011 Wiley-Liss, Inc. J. Med.
Keywords acute hepatitis C
risk factors
Language English
Date 2011-10-01
Published in Journal of Medical Virology. Malden: Wiley-Blackwell, v. 83, n. 10, p. 1738-1743, 2011.
ISSN 0146-6615 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 1738-1743
Access rights Closed access
Type Article
Web of Science ID WOS:000293985900009

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