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dc.contributor.authorQuintino, Marisa Pascale [UNIFESP]
dc.contributor.authorNakamura, Mary Uchiyama [UNIFESP]
dc.contributor.authorSimoes, Manuel de Jesus [UNIFESP]
dc.contributor.authorAraujo Junior, Edward [UNIFESP]
dc.contributor.authorOliveira Filho, Ricardo Martins de [UNIFESP]
dc.contributor.authorTorloni, Maria Regina [UNIFESP]
dc.contributor.authorEspiridião, Silvia [UNIFESP]
dc.contributor.authorKulay Júnior, Luiz [UNIFESP]
dc.identifier.citationJournal of Obstetrics and Gynaecology Research. Malden: Wiley-Blackwell, v. 37, n. 9, p. 1212-1215, 2011.
dc.description.abstractAim: Assess possible adverse effects of the chronic use of indinavir during pregnancy in a rat model.Methods: 40 pregnant EOM-1 albino rats were randomly allocated into four groups of 10 animals each: a control (Ctr) group (without any handling) and three experimental groups (Exp 1, Exp 2 e Exp 3) which received indinavir 9, 27 e 81 mg/kg, respectively). Rats were treated by gavage once daily. the treatment period extended from day 0 until the 20th day of pregnancy. Body weights were recorded on days 0, 7, 14 and 20. At term, the rats were sacrificed, and the implantation sites, number of live and dead fetuses and placentas, resorptions, fetal and placental weights were recorded. the fetuses were evaluated for external abnormalities under a stereomicroscope.Results: Weight gain during pregnancy did not differ significantly between the groups. Average weight gains between the 7th and 20th day were 7.95-42.70 g; 7.22-45.27 g; 7.12-46.26 g and 8.05-42.29 g in groups Ctr, Exp 1, Exp 2 and Exp 3, respectively. All other parameters assessed did not differ significantly between groups.Conclusions: Chronic use of various dosages of indinavir during pregnancy was not associated significant adverse outcomes.en
dc.relation.ispartofJournal of Obstetrics and Gynaecology Research
dc.rightsAcesso restrito
dc.subjectbiological assayen
dc.titleChronic use of indinavir in albino rat pregnancy (Rattus norvegicus albinus, Rodentia, Mammalia): Biological assayen
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionABC Fdn
dc.description.affiliationSão Paulo Fed Univ UNIFESP, Dept Obstet, BR-05303000 São Paulo, Brazil
dc.description.affiliationSão Paulo Univ USP, Dept Pharmacol, São Paulo, Brazil
dc.description.affiliationABC Fdn, Dept Maternal & Child Hlth, Fac Med, Santo Andre, SP, Brazil
dc.description.affiliationUnifespSão Paulo Fed Univ UNIFESP, Dept Obstet, BR-05303000 São Paulo, Brazil
dc.description.sourceWeb of Science

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