In utero exposure to air pollution lowers erythrocyte antioxidant defense and decreases weight in adult mice
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2011-09-01
Autores
Abe, Karina Camasmie [UNIFESP]
Brandao, Leticia de Campos [UNIFESP]
Tufik, Sergio [UNIFESP]
Nascimento Saldiva, Paulo Hilario do
D'Almeida, Vania [UNIFESP]
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In this study, we tested the influence of ambient air pollution on different phases of development of adult mice. With respect to adult weight, the animals that had spent their in utero period exposed to pollution showed less weight gain over their lifetime, as well as lower activity levels of the antioxidant enzymes catalase, superoxide dismutase (SOD) and glutathione peroxidase (GPx). Our study suggests that contact with atmospheric pollutants during the foetal period produces important changes on enzymatic erythrocyte antioxidant defense and weight in adult mice. (C) 2011 Elsevier B.V. All rights reserved.
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Environmental Toxicology and Pharmacology. Amsterdam: Elsevier B.V., v. 32, n. 2, p. 315-318, 2011.