Prostatic carcinomas with neuroendocrine differentiation diagnosed in needle biopsies, a morphologic study of 7 cases among 465 sequential biopsies in a tertiary cancer center

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dc.contributor.author Lima, M. V. A.
dc.contributor.author Nogueira, C.
dc.contributor.author Oliveira, J. A. A.
dc.contributor.author Muniz Neto, F. J.
dc.contributor.author Franco, M. [UNIFESP]
dc.contributor.author Tavora, Fabio Rocha Fernandes [UNIFESP]
dc.date.accessioned 2016-01-24T14:17:08Z
dc.date.available 2016-01-24T14:17:08Z
dc.date.issued 2011-09-01
dc.identifier http://dx.doi.org/10.1590/S1677-55382011000500005
dc.identifier.citation International Braz J Urol. Rio de Janeiro: Brazilian Soc Urol, v. 37, n. 5, p. 598-604, 2011.
dc.identifier.issn 1677-5538
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/33991
dc.description.abstract Purpose: Neuroendocrine carcinomas (NEC) of the prostate are rare, with only a few series hitherto reported. the objective of this study was to assess in a single institution the clinical and morphologic characteristics of neuroendocrine carcinomas diagnosed in needle core biopsies.Materials and Methods: the current study analyses seven cases diagnosed in needle biopsies at a large tertiary regional cancer center from Northeastern Brazil. Two pathologists reviewed specimens retrospectively, and demographic and morphologic characteristics were compared to 458 acinar tumors diagnosed in the same period.Results: There were five small cell carcinomas and two low-grade neuroendocrine carcinomas (carcinoid). NEC were associated with an acinar component in 5/7 cases and the Gleason score of the acinar component was always > 6. the number of cores involved in prostates with NEC was greater (65% compared to 24% of acinar tumors, p < 0.05). the mean PSA at diagnosis was 417.7 (range 5.7-1593, SD 218.3), compared to 100.5 (p = 0.1) of acinar tumors (range 0.3-8545, SD 22.7). Prostates harboring NEC were bigger (p < 0.001, mean volume 240 mL vs. 53 mL of acinar tumors). Treatment of NEC included palliative surgery, chemotherapy, and hormonal therapy.Conclusions: NEC of the prostate is rare and often associated with a high-grade acinar component. Prostates with NEC tend to be larger and involve a greater number of cores than acinar tumors. PSA at diagnosis does not seem to predict the presence of NE tumors in needle biopsy. en
dc.format.extent 598-604
dc.language.iso eng
dc.publisher Brazilian Soc Urol
dc.relation.ispartof International Braz J Urol
dc.rights Acesso aberto
dc.subject prostate en
dc.subject neoplasms en
dc.subject carcinoid tumor en
dc.subject neuroendocrine tumor en
dc.subject treatment outcome en
dc.title Prostatic carcinomas with neuroendocrine differentiation diagnosed in needle biopsies, a morphologic study of 7 cases among 465 sequential biopsies in a tertiary cancer center en
dc.type Artigo
dc.contributor.institution Hosp Canc
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Hosp Canc, Inst Canc Ceara, BR-60430230 Fortaleza, Ceara, Brazil
dc.description.affiliation Escola Paulista Med, BR-04023 São Paulo, Brazil
dc.description.affiliationUnifesp Escola Paulista Med, BR-04023 São Paulo, Brazil
dc.identifier.scielo S1677-55382011000500005
dc.identifier.doi 10.1590/S1677-55382011000500005
dc.description.source Web of Science
dc.identifier.wos WOS:000299854100005



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