Prostatic carcinomas with neuroendocrine differentiation diagnosed in needle biopsies, a morphologic study of 7 cases among 465 sequential biopsies in a tertiary cancer center

Prostatic carcinomas with neuroendocrine differentiation diagnosed in needle biopsies, a morphologic study of 7 cases among 465 sequential biopsies in a tertiary cancer center

Author Lima, M. V. A. Google Scholar
Nogueira, C. Google Scholar
Oliveira, J. A. A. Google Scholar
Muniz Neto, F. J. Google Scholar
Franco, M. Autor UNIFESP Google Scholar
Tavora, Fabio Rocha Fernandes Autor UNIFESP Google Scholar
Institution Hosp Canc
Universidade Federal de São Paulo (UNIFESP)
Abstract Purpose: Neuroendocrine carcinomas (NEC) of the prostate are rare, with only a few series hitherto reported. the objective of this study was to assess in a single institution the clinical and morphologic characteristics of neuroendocrine carcinomas diagnosed in needle core biopsies.Materials and Methods: the current study analyses seven cases diagnosed in needle biopsies at a large tertiary regional cancer center from Northeastern Brazil. Two pathologists reviewed specimens retrospectively, and demographic and morphologic characteristics were compared to 458 acinar tumors diagnosed in the same period.Results: There were five small cell carcinomas and two low-grade neuroendocrine carcinomas (carcinoid). NEC were associated with an acinar component in 5/7 cases and the Gleason score of the acinar component was always > 6. the number of cores involved in prostates with NEC was greater (65% compared to 24% of acinar tumors, p < 0.05). the mean PSA at diagnosis was 417.7 (range 5.7-1593, SD 218.3), compared to 100.5 (p = 0.1) of acinar tumors (range 0.3-8545, SD 22.7). Prostates harboring NEC were bigger (p < 0.001, mean volume 240 mL vs. 53 mL of acinar tumors). Treatment of NEC included palliative surgery, chemotherapy, and hormonal therapy.Conclusions: NEC of the prostate is rare and often associated with a high-grade acinar component. Prostates with NEC tend to be larger and involve a greater number of cores than acinar tumors. PSA at diagnosis does not seem to predict the presence of NE tumors in needle biopsy.
Keywords prostate
neoplasms
carcinoid tumor
neuroendocrine tumor
treatment outcome
Language English
Date 2011-09-01
Published in International Braz J Urol. Rio de Janeiro: Brazilian Soc Urol, v. 37, n. 5, p. 598-604, 2011.
ISSN 1677-5538 (Sherpa/Romeo, impact factor)
Publisher Brazilian Soc Urol
Extent 598-604
Origin http://dx.doi.org/10.1590/S1677-55382011000500005
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000299854100005
SciELO ID S1677-55382011000500005 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/33991

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