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dc.contributor.authorSmith, Gary D.
dc.contributor.authorMotta, Eduardo E. [UNIFESP]
dc.contributor.authorSerafini, Paulo
dc.identifier.citationReproductive Biomedicine Online. Oxford: Elsevier B.V., v. 23, n. 3, p. 298-306, 2011.
dc.description.abstractIn the last decades significant advances have been made in successful cryopreservation of mammalian oocytes. Human oocyte cryopreservation has practical application in preserving fertility for individuals at risk of compromised egg quality due to cancer treatments or advanced maternal age. While oocyte cryopreservation success has increased over time, there is still room for improvement. Oocytes are susceptible to cryodamage; which collectively entails cellular damage caused by mechanical, chemical or thermal forces during the vitrification and warming process. This review will delineate many of the oocyte intracellular and extracellular structures that are/may be stressed and/or compromised during cryopreservation. This will be followed by a discussion of the theoretical basis of oocyte vitrification and warming, and a non-exhaustive review of current experimental data and clinical expectations of oocyte vitrification will be presented. Finally, a forward-thinking vision of a potential means of modifying and improving vitrification and warming procedures and success will be proposed. (C) 2011, Reproductive Healthcare Ltd. Published by Elsevier B.V. All rights reserved.en
dc.publisherElsevier B.V.
dc.relation.ispartofReproductive Biomedicine Online
dc.rightsAcesso aberto
dc.titleTheoretical and experimental basis of oocyte vitrificationen
dc.contributor.institutionUniv Michigan
dc.contributor.institutionHuntington Ctr Reprod Med Brazil
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationUniv Michigan, Dept Obstet & Gynecol, Ann Arbor, MI 48109 USA
dc.description.affiliationUniv Michigan, Dept Urol, Ann Arbor, MI 48109 USA
dc.description.affiliationUniv Michigan, Reprod Sci Program, Ann Arbor, MI 48109 USA
dc.description.affiliationHuntington Ctr Reprod Med Brazil, BR-04501000 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Obstet & Gynecol, BR-04023900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Gynecol, BR-05403000 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Obstet & Gynecol, BR-04023900 São Paulo, Brazil
dc.description.sourceWeb of Science

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