Dimensional correlates of poor insight in obsessive-compulsive disorder
Torres, Albina Rodrigues
Fontenelle, Leonardo Franklin
Rosario, Maria Conceicao do [UNIFESP]
Ferroo, Ygor Arzeno
Mathis, Maria Alice de
Miguel, Euripedes Constantino
Bloch, Michael H.
Is part ofProgress in Neuro-psychopharmacology & Biological Psychiatry
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Background: Cross-sectional studies have associated poor insight in patients with obsessive-compulsive disorder (OCD) with increased OCD symptom severity, earlier age of onset, comorbid depression, and treatment response. the goal of this current study was to examine the relationship between dimensions of OCD symptomatology and insight in a large clinical cohort of Brazilian patients with OCD. We hypothesized that poor insight would be associated with total symptom severity as well as with hoarding symptoms severity, specifically.Methods: 824 outpatients underwent a detailed clinical assessment for OCD, including the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), the Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS), the Brown Assessment of Beliefs Scale (BABS), a socio-demographic questionnaire, and the Structured Clinical Interview for axis I DSM-IV disorders (SCID-P). Tobit regression models were used to examine the association between level of insight and clinical variables of interest.Results: Increased severity of current and worst-ever hoarding symptoms and higher rate of unemployment were associated with poor insight in OCD after controlling for current OCD severity, age and gender. Poor insight was also correlated with increased severity of current OCD symptoms.Conclusion: Hoarding and overall OCD severity were significantly but weakly associated with level of insight in OCD patients. Further studies should examine insight as a moderator and mediator of treatment response in OCD in both behavioral therapy and pharmacological trials. Behavioral techniques aimed at enhancing insight may be potentially beneficial in OCD, especially among patients with hoarding. (C) 2011 Published by Elsevier Inc.
CitationProgress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 35, n. 7, p. 1677-1681, 2011.
SponsorshipNational Institute of Mental Health
Yale Child Study Center
National Institutes of Health
Trichotillomania Learning Center
Doris Duke Charitable Foundation
National Center for Research Resources, a component of the National Institutes of Health
NIH roadmap for Medical Research
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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