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dc.contributor.authorSiqueira das Neves, Lais Mara
dc.contributor.authorMarcolino, Alexandre Marcio
dc.contributor.authorPrado, Rodrigo Paschoal
dc.contributor.authorRibeiro, Tiago de Souza
dc.contributor.authorPinfildi, Carlos Eduardo [UNIFESP]
dc.contributor.authorThomazini, Jose Antonio
dc.identifier.citationPhotomedicine and Laser Surgery. New Rochelle: Mary Ann Liebert Inc, v. 29, n. 8, p. 581-587, 2011.
dc.description.abstractObjective: the purpose of this study was to evaluate the effect of 830-nm laser in blocking the action of nicotine on the viability of skin flap. Background data: the authors have analyzed the deleterious effect of cigarette smoke or nicotine on the skin flap alone with evidence of increased skin necrosis in the flap. Materials and methods: Twenty-four Wistar-albino rats were divided into three groups of eight animals each: Group 1 (control), subjected to a surgical technique to obtain a flap for cranial base, laser irradiation simulation, and a subcutaneous injection of saline; Group 2, similar to Group 1, with subcutaneous injection of nicotine (2mg/kg/day) for a period of 1 week before and 1 week after surgery; and Group 3, similar to Group 2, with skin flaps subjected to a lambda 830-nm laser irradiation. the laser parameters used were: power 30 mW, beam area 0.07cm(2), irradiance 429 mW/cm(2), irradiation time 84 sec, total energy 2.52J, and energy density 36J/cm(2). the laser was used immediately after surgery and for 4 consecutive days, in one point at 2.5 cm of the flap cranial base. the areas of necrosis were examined by two macroscopic analyses: paper template and Mini-Mop (R). the pervious blood vessels were also counted. Results: the results were statistically analyzed by ANOVA and post-test contrast orthogonal method (multiple comparisons), showing that the laser decreased the area of necrosis in flaps subjected to nicotine, and consequently, increased the number of blood vessels (p < 0.05). Conclusions: the laser proved to be an effective way to decrease the area of necrosis in rats subjected to nicotine, making them similar to the control group.en
dc.publisherMary Ann Liebert Inc
dc.relation.ispartofPhotomedicine and Laser Surgery
dc.rightsAcesso restrito
dc.titleLow-Level Laser Therapy on the Viability of Skin Flap in Rats Subjected to Deleterious Effect of Nicotineen
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionFed Univ Goias Campus Jatai
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniv São Paulo, FMRP USP, Dept Biomech Med & Rehabil Locomotor Syst, BR-14049 Ribeirao Preto, Brazil
dc.description.affiliationFed Univ Goias Campus Jatai, Dept Physiotherapy, Jatai, Go, Brazil
dc.description.affiliationUniv São Paulo, FMRP USP, Dept Clin Surg, BR-14049 Ribeirao Preto, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Plast Surg, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Plast Surg, São Paulo, Brazil
dc.description.sourceWeb of Science

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