alpha-Pinene isolated from Schinus terebintinfolius Raddi (Anacardiaceae) induces apoptosis and confers antimetastatic protection in a melanoma model

alpha-Pinene isolated from Schinus terebintinfolius Raddi (Anacardiaceae) induces apoptosis and confers antimetastatic protection in a melanoma model

Author Matsuo, Alisson Leonardo Autor UNIFESP Google Scholar
Figueiredo, Carlos Rogerio Autor UNIFESP Google Scholar
Arruda, Denise Costa Autor UNIFESP Google Scholar
Pereira, Felipe Valença Autor UNIFESP Google Scholar
Scutti, Jorge Augusto Borin Autor UNIFESP Google Scholar
Massaoka, Mariana Hiromi Autor UNIFESP Google Scholar
Travassos, Luiz Rodolpho Autor UNIFESP Google Scholar
Sartorelli, Patricia Autor UNIFESP Google Scholar
Lago, Joao Henrique Ghilardi Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Malignant melanoma is one the most aggressive types of cancer and its incidence has gradually increased in the last years, accounting for about 75% of skin cancer deaths. This poor prognosis results from the tumor resistance to conventional drugs mainly by deregulation of apoptotic pathways. the aim of this work was to investigate the cell death mechanism induced by alpha-pinene and its therapeutic application. Our results demonstrated that alpha-pinene was able to induce apoptosis evidenced by early disruption of the mitochondrial potential, production of reactive oxygen species, increase in caspase-3 activity, heterochromatin aggregation, DNA fragmentation and exposure of phosphatidyl serine on the cell surface. Most importantly, this molecule was very effective in the treatment of experimental metastatic melanoma reducing the number of lung tumor nodules. This is the first report on the apoptotic and antimetastatic activity of isolated alpha-pinene. (C) 2011 Elsevier Inc. All rights reserved.
Keywords alpha-Pinene
Melanoma
Apoptosis
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2011-07-29
Published in Biochemical and Biophysical Research Communications. San Diego: Academic Press Inc Elsevier Science, v. 411, n. 2, p. 449-454, 2011.
ISSN 0006-291X (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 449-454
Origin http://dx.doi.org/10.1016/j.bbrc.2011.06.176
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000293809900039
URI http://repositorio.unifesp.br/handle/11600/33892

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