Adhesio interthalamica alterations in schizophrenia spectrum disorders: A systematic review and meta-analysis

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Trzesniak, Clarissa
Kempton, Matthew J.
Busatto, Geraldo F.
Oliveira, Irismar Reis de
Galvao-de Almeida, Amanda [UNIFESP]
Kambeitz, Joseph
Freitas Ferrari, Maria Cecilia
Santos Filho, Alaor
Chagas, Marcos H. N.
Zuardi, Antonio W.
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Magnetic resonance imaging (MRI) studies have reported a variety of brain abnormalities in association with schizophrenia. These include a higher prevalence of an absent adhesio interthalamica (Al; also known massa intermedia), a gray matter junction that is present between the two thalami in approximately 80% of healthy subjects. in this meta-analytic review, we describe and discuss the main Al MRI findings in schizophrenia spectrum disorders (SSDs) to date. the MEDLINE and ISI Web of Knowledge(SM) databases were searched up to December 2010, for studies that used MRI to assess Al in patients with SSD and controls. From fourteen potential reports, eleven were eligible to be part of the current review. These studies included 822 patients with SSD and 718 healthy volunteers. There was a large degree of variability in the MRI methods they employed. Patients with SSD had a higher prevalence of absent Al than healthy volunteers (odds ratio = 1.98; 95% confidence interval 1.33-2.94: p=0.0008). This association was evident in both male and female SSD subjects, and there was no evidence that the prevalence was related to age or duration of illness. the significance of the absence of an Al for SSD may be clarified by studies in large, longitudinal community-based samples using standardized methods. (C) 2011 Elsevier Inc. All rights reserved.
Progress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 35, n. 4, p. 877-886, 2011.