P-Glycoprotein Expression, Tumor Weight, Age, and Relapse in Patients with Stage I and II Favorable-Histology Wilms' Tumor

Date
2011-04-01Author
Plaza Teixeira, Roberto Augusto
Odone-Filho, Vicente
Camargo, Beatriz de
Zerbini, Maria Claudia
Fillipi, Renne
Alencar, Arlaine
Cristofani, Lilian
Type
ArtigoISSN
0888-0018Is part of
Pediatric Hematology and OncologyDOI
10.3109/08880018.2010.533250Metadata
Show full item recordAbstract
Fifteen percent of patients with Wilms'' tumor (WT) experience relapse. It has been suggested that weight and age may affect the chances of relapse. Few studies have investigated the role, if any, between P-glycoprotein (P-gp) and relapse. the authors assessed the prognostic value of tumor weight and age at diagnosis and asked whether some other potential biological markers, specifically P-gp protein expression, had a prognostic value in favorable-histology WT. No association between age and relapse could be found. Patients with tumor weight >= a parts per thousand yen550 g were 6 times more likely to relapse, whereas P-gp expression was positive in 18/40 (45%%) of the patients, of which 10/12 (83.3%%) relapsed and 8/28 (28.6%%) did not. Further studies are necessary to elucidate whether or not P-gp is related to relapse in patients with histologically favorable Wilms'' tumor. If confirmed, the protein may be used in the future as a target for new drugs and treatments for this group of patients.</.
Citation
Pediatric Hematology and Oncology. London: Informa Healthcare, v. 28, n. 3, p. 194-202, 2011.Collections
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