The Association Between Primary Antiretroviral Resistance and HAART Virologic Failure in a Developing Set

The Association Between Primary Antiretroviral Resistance and HAART Virologic Failure in a Developing Set

Author Gagliani, Luiz Henrique Google Scholar
Alkmim Maia, Wagner T. Google Scholar
Sa-Filho, Dercy Google Scholar
Janini, Luiz Mario Google Scholar
Sucupira, Maria Cecilia Google Scholar
Caseiro, Marcos Montani Google Scholar
Diaz, Ricardo Sobhie Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Ctr Univ Lusiada
Abstract Santos is a Brazilian port city with high HIV incidence, high primary antiretroviral resistance levels, high HIV-1 BF recombinants prevalence, and high rates of antiretroviral virologic failure. We evaluated factors related to virologic failure after 48 weeks of HAART in this population. We compared demographic and HIV profiles among 43 individuals with virologic failure (group 1) and 37 with virologic success (group 2) after 48 weeks of HAART initiation. the overall primary antiretroviral resistance prevalence was 31.2%; 46.5% in group 1 and 13.5% in group 2 (p < 0.005). Nine patients from group 1 and seven from group 2 were infected by F or BF strains. Fifteen individuals presented with NRTI mutations, 13 with NNRTI mutations, three with PI mutations, and five with NRTI and NNRTI mutations. No significant differences were observed in baseline viral load, CD4, clade assignment, antiretrovirals used, or demographics among groups or patients harboring resistant versus wild-type viruses. in this region, there was a high prevalence of antiretroviral resistance among long standing infected patients whose disease had progressed. This finding supports the concept that resistance testing prior to ART initiation is cost effective. the association between primary antiretroviral resistance and virologic failure may suggest that primary resistance greatly impairs antiretroviral activity.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 06/52722-6
Date 2011-03-01
Published in Aids Research and Human Retroviruses. New Rochelle: Mary Ann Liebert Inc, v. 27, n. 3, p. 251-256, 2011.
ISSN 0889-2229 (Sherpa/Romeo, impact factor)
Publisher Mary Ann Liebert Inc
Extent 251-256
Access rights Closed access
Type Article
Web of Science ID WOS:000288241600005

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