Analysis of the Origin and Evolutionary History of HIV-1 CRF28_BF and CRF29_BF Reveals a Decreasing Prevalence in the AIDS Epidemic of Brazil

Analysis of the Origin and Evolutionary History of HIV-1 CRF28_BF and CRF29_BF Reveals a Decreasing Prevalence in the AIDS Epidemic of Brazil

Author Ristic, Natalia Google Scholar
Zukurov, Jean Autor UNIFESP Google Scholar
Alkmim, Wagner Autor UNIFESP Google Scholar
Diaz, Ricardo Sobhie Autor UNIFESP Google Scholar
Janini, Luiz Mario Autor UNIFESP Google Scholar
Chin, Mario P. S. Google Scholar
Institution Rockefeller Univ
Universidade Federal de São Paulo (UNIFESP)
Abstract Background: HIV-1 subtype B and subtype F are prevalent in the AIDS epidemic of Brazil. Recombinations between these subtypes have generated at least four BF circulating recombinant forms (CRFs). CRF28_BF and CRF29_BF are among the first two BF recombinants being identified in Brazil and they contributed significantly to the epidemic. However, the evolution and demographic histories of the CRFs are unclear.Methodology/Principal Findings: A collection of gag and pol sequences sampled within Brazil was screened for CRF28_BF-like and CRF29_BF-like recombination patterns. A Bayesian coalescent framework was employed to delineate the phylogenetic, divergence time and population dynamics of the virus having CRF28_BF-like and CRF29_BF-like genotype. These recombinants were phylogenetically related to each other and formed a well-supported monophyletic clade dated to 1988-1989. the effective number of infections by these recombinants grew exponentially over a five-year period after their emergence, but then decreased toward the present following a logistic model of population growth. the demographic pattern of both recombinants closely resembles those previously reported for CRF31_BC.Conclusions: We revealed that HIV-1 recombinants of the CRF28_BF/CRF29_BF clade are still circulating in the Brazilian population. These recombinants did not exhibit a strong founder effect and showed a decreasing prevalence in the AIDS epidemic of Brazil. Our data suggested that multiple URFs may also play a role in shaping the epidemic of recombinant BF HIV-1 in the region.
Language English
Sponsor Aaron Diamond AIDS Research Center
National Institutes of Health
Grant number National Institutes of Health: DA026293
Date 2011-03-01
Published in Plos One. San Francisco: Public Library Science, v. 6, n. 3, 8 p., 2011.
ISSN 1932-6203 (Sherpa/Romeo, impact factor)
Publisher Public Library Science
Extent 8
Origin http://dx.doi.org/10.1371/journal.pone.0017485
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000287932100020
URI http://repositorio.unifesp.br/handle/11600/33496

Show full item record




File

Name: WOS000287932100020.pdf
Size: 450.7Kb
Format: PDF
Description:
Open file

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account