SMARCA5 Methylation and Expression in Gastric Cancer

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2011-02-01
Autores
Gigek, Carolina Oliveira
Frias Lisboa, Luara Carolina
Leal, Mariana Ferreira
Oliveira Silva, Patricia Natalia
Lima, Eleonidas Moura
Khayat, Andre Salim
Assumpcao, Paulo Pimentel
Burbano, Rommel Rodriguez
Cardoso Smith, Marilia de Arruda [UNIFESP]
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Here, we first evaluated SMARCA5 expression and promoter DNA methylation in gastric carcinogenesis. lmmunohistochemistry and methylation-specific PCR were analyzed in 19 and 48 normal mucosa and in 52 and 92 gastric cancer samples, respectively. We observed higher immunoreactivity of SMARCA5 in gastric cancer samples than in normal mucosa. Moreover, SMARCA5 promoter methylation was associated with the absence of protein expression. Our findings suggest that SMARCA5 has a potential role in proliferation and malignancy in gastric carcinogenesis.
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Cancer Investigation. London: Informa Healthcare, v. 29, n. 2, p. 162-166, 2011.