Hormonal profile, the PROGINS polymorphism, and erectile dysfunction complaints: data from a population-based survey

Hormonal profile, the PROGINS polymorphism, and erectile dysfunction complaints: data from a population-based survey

Author Andersen, Monica L. Autor UNIFESP Google Scholar
Alvarenga, Tathiana A. Autor UNIFESP Google Scholar
Mazzotti, Diego R. Autor UNIFESP Google Scholar
Guindalini, Camila Autor UNIFESP Google Scholar
Pellegrino, Renata Autor UNIFESP Google Scholar
Barrueco, Karina F. Autor UNIFESP Google Scholar
Santos-Silva, Rogerio Autor UNIFESP Google Scholar
Bittencourt, Lia R. Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: To evaluate a potential association among the hormonal profile, PROGINS polymorphism, and erectile dysfunction (ED) complaints in a large population-based sample in São Paulo, Brazil.Design: Population-based questionnaire study.Setting: Interviews, sleep recording, and blood sample were conducted in a sleep institute.Patient(s): the total study participants included 467 men.Intervention(s): General information was obtained through interviews, and a blood sample was collected for hormone levels, DNA extraction, and PROGINS genotyping.Main Outcome Measure(s): the effect of progesterone and the PROGINS polymorphism on the risk of developing ED were measured by questionnaire and blood sample.Result(s): Progesterone, prolactin, testosterone, and estradiol levels did not differ between the genotype groups (T1/T1 and T1/T2+T2/T2). No significant genotypic or allelic differences were found between individuals with ED complaints and controls. Multivariate logistic regression analyses including age, body mass index, hypertension, diabetes, apnea-hypopnea index, and genetic ancestry estimation, as well as the PROGINS polymorphism, confirmed the lack of association between the T2 allele carriers and the risk of ED(odds ratio = 0.80; 95% confidence interval = 0.40-1.62).Conclusion(s): This is the first study to demonstrate the genotypic and allelic frequencies of the PROGINS polymorphism in a large population-based sample of men. the results do not support a direct role for the PROGINS polymorphism in the risk of developing ED; however, further examination of other variants within PR gene will be necessary to completely rule out an effect. (Fertil Steril (R) 2011;95:621-4. (C) 2011 by American Society for Reproductive Medicine.)
Keywords Sleep
erectile dysfunction
Language English
Sponsor Associacao Fundo de Incentivo a Psicofarmacologia (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 07/50525-1
FAPESP: 09/01030-5
FAPESP: 98/14303-3
Date 2011-02-01
Published in Fertility and Sterility. New York: Elsevier B.V., v. 95, n. 2, p. 621-624, 2011.
ISSN 0015-0282 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 621-624
Origin http://dx.doi.org/10.1016/j.fertnstert.2010.10.012
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000286419000042
URI http://repositorio.unifesp.br/handle/11600/33371

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