Development of Bladder Dysfunction in a Rat Model of Dopaminergic Brain Lesion

Development of Bladder Dysfunction in a Rat Model of Dopaminergic Brain Lesion

Author Soler, Roberto Autor UNIFESP Google Scholar
Fuellhase, Claudius Google Scholar
Santos, Cesar Google Scholar
Andersson, Karl-Erik Google Scholar
Institution Wake Forest Univ
Universidade Federal de São Paulo (UNIFESP)
Ludwig Maximilians Univ Munchen
Abstract Aims: Parkinson's disease (PD) is one of the most common neurological disorders causing lower urinary tract dysfunction. We evaluated the temporal development of bladder dysfunction in rat PD model where urodynamic changes were induced by unilateral injection of 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle (MFB). Methods: Female Sprague--Dawley rats underwent a unilateral stereotaxic injection of 6-OHDA or vehicle (sham group) into the MFB. Cystometry was performed in conscious animals at 3, 14, and 28 days after the injury. Aged-matched unlesioned rats were used as healthy controls. Results: Three days after lesion 6-OHDA rats showed higher threshold (TP), maximum pressures (MP), and spontaneous activity (SA) compared to healthy controls. Sham animals exhibited higher TP. After 14 days 6-OHDA rats had also higher micturition frequency, decreased bladder capacity, micturition volume and bladder compliance (Bcom) compared to sham and healthy controls. Sham animals showed lower Bcom and higher MP and SA. After 28 days, 6-OHDA rats exhibited the same changes as those in 14 days, while sham-operated animals showed parameters similar to those in healthy controls. Conclusions: These findings suggest that 6-OHDA lesion of the MFB causes bladder dysfunction already after 3 days. A pattern of detrusor overactivity was more clearly defined 14 days after the injection and persisted for 28 days. Cystometry may be a useful tool to study the pathophysiology of bladder dysfunction in PD, and urodynamic parameters may possibly be used to evaluate the effects of therapeutic interventions. Neurourol. Urodynam. 30: 188-193, 2011. (C) 2010 Wiley-Liss, Inc.
Keywords 6-hydroxydopamine
bladder dysfunction
Parkinson's disease
Language English
Date 2011-01-01
Published in Neurourology and Urodynamics. Malden: Wiley-Blackwell, v. 30, n. 1, p. 188-193, 2011.
ISSN 0733-2467 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 188-193
Origin http://dx.doi.org/10.1002/nau.20917
Access rights Closed access
Type Article
Web of Science ID WOS:000285980300033
URI http://repositorio.unifesp.br/handle/11600/33254

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