The Paracoccidioides cell wall: past and present layers toward understanding interaction with the host

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Date
2011-01-01Author
Puccia, Rosana [UNIFESP]
Vallejo, Milene Carmes [UNIFESP]
Matsuo, Alisson Leonardo [UNIFESP]
Longo, Larissa Valle Guilhen [UNIFESP]
Type
ResenhaISSN
1664-302XIs part of
Frontiers in MicrobiologyDOI
10.3389/fmicb.2011.00257Metadata
Show full item recordAbstract
The cell wall of pathogenic fungi plays import roles in the interaction with the host, so that its composition and structure may determine the course of infection. Here we present an overview of the current and past knowledge on the cell wall constituents of Paracoccidioides brasiliensis and P. lutzii. These are temperature-dependent dimorphic fungi that cause paracoccidioidomycosis, a systemic granulomatous, and debilitating disease. Focus is given on cell wall carbohydrate and protein contents, their immune-stimulatory features, adhesion properties, drug target characteristics, and morphological phase specificity. We offer a journey toward the future understanding of the dynamic nature of the cell wall and of the changes that may occur when the fungus infects the human host.
Citation
Frontiers in Microbiology. Lausanne: Frontiers Research Foundation, v. 2, 7 p., 2011.Keywords
cell wallParacoccidioides brasiliensis
P. lutzii
polysaccharides
adhesins
enzymes
host interaction
Sponsorship
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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