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dc.contributor.authorHerculano-Houzel, Suzana
dc.contributor.authorRibeiro, Pedro
dc.contributor.authorCampos, Leandro
dc.contributor.authorSilva, Alexandre Valotta da [UNIFESP]
dc.contributor.authorTorres, Laila Brito [UNIFESP]
dc.contributor.authorCatania, Kenneth C.
dc.contributor.authorKaas, Jon H.
dc.identifier.citationBrain Behavior and Evolution. Basel: Karger, v. 78, n. 4, p. 302-314, 2011.
dc.description.abstractBrain size scales as different functions of its number of neurons across mammalian orders such as rodents, primates, and insectivores. in rodents, we have previously shown that, across a sample of 6 species, from mouse to capybara, the cerebral cortex, cerebellum and the remaining brain structures increase in size faster than they gain neurons, with an accompanying decrease in neuronal density in these structures [Herculano-Houzel et al.: Proc Natl Acad Sci USA 2006; 103: 12138-12143]. Important remaining questions are whether such neuronal scaling rules within an order apply equally to all pertaining species, and whether they extend to closely related taxa. Here, we examine whether 4 other species of Rodentia, as well as the closely related rabbit (Lagomorpha), conform to the scaling rules identified previously for rodents. We report the updated neuronal scaling rules obtained for the average values of each species in a way that is directly comparable to the scaling rules that apply to primates [Gabi et al.: Brain Behav Evol 2010; 76: 32-44], and examine whether the scaling relationships are affected when phylogenetic relatedness in the dataset is accounted for. We have found that the brains of the spiny rat, squirrel, prairie dog and rabbit conform to the neuronal scaling rules that apply to the previous sample of rodents. the conformity to the previous rules of the new set of species, which includes the rabbit, suggests that the cellular scaling rules we have identified apply to rodents in general, and probably to Glires as a whole (rodents/lagomorphs), with one notable exception: the naked mole-rat brain is apparently an outlier, with only about half of the neurons expected from its brain size in its cerebral cortex and cerebellum. Copyright (C) 2011 S. Karger AG, Baselen
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipJames S. McDonnell Foundation
dc.relation.ispartofBrain Behavior and Evolution
dc.rightsAcesso aberto
dc.subjectBrain sizeen
dc.titleUpdated Neuronal Scaling Rules for the Brains of Glires (Rodents/Lagomorphs)en
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionVanderbilt Univ
dc.description.affiliationUFRJ, Inst Ciencias Biomed, BR-21941902 Rio de Janeiro, RJ, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biociencias, São Paulo, Brazil
dc.description.affiliationVanderbilt Univ, Dept Biol, Nashville, TN 37235 USA
dc.description.affiliationVanderbilt Univ, Dept Psychol, Nashville, TN 37240 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biociencias, São Paulo, Brazil
dc.description.sponsorshipIDNSF: 0844743
dc.description.sponsorshipIDNEI: EY02686
dc.description.sourceWeb of Science

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