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dc.contributor.authorMiyamoto, Maristela
dc.contributor.authorPessoa, Silvana D.
dc.contributor.authorOno, Erika
dc.contributor.authorMachado, Daisy M.
dc.contributor.authorSalomão, Reinaldo [UNIFESP]
dc.contributor.authorSucci, Regina C. de M.
dc.contributor.authorPahwa, Savita
dc.contributor.authorMoraes-Pinto, Maria Isabel de [UNIFESP]
dc.identifier.citationJournal of Tropical Pediatrics. Oxford: Oxford Univ Press, v. 56, n. 6, p. 427-432, 2010.
dc.description.abstractLymphocyte subsets, activation markers and apoptosis were assessed in 20 HIV-exposed noninfected (ENI) children born to HIV-infected women who were or not exposed to antiretroviral (ARV) drugs during pregnancy and early infancy. ENI children and adolescents were aged 6-18 years and they were compared to 25 age-matched healthy non-HIV-exposed children and adolescents (Control). ENI individuals presented lower CD4(+) T cells/mm(3) than Control group (control: 1120.3 vs. ENI: 876.3; t-test, p=0.030). ENI individuals had higher B-cell apoptosis than Control group (Control: 36.6%, ARV exposed: 82.3%, ARV nonexposed: 68.5%; Kruskal-Wallis, p < 0.05), but no statistical difference was noticed between those exposed and not exposed to ARV. Immune activation in CD4(+) T, CD8(+) T and in B cells was comparable in ENI and in Control children and adolescents. Subtle long-term immune alterations might persist among ENI individuals, but the clinical consequences if any are unknown, and these children require continued monitoring.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipMiami Fogarty
dc.description.sponsorshipMiami Developmental Center for AIDS Research
dc.publisherOxford Univ Press
dc.relation.ispartofJournal of Tropical Pediatrics
dc.rightsAcesso restrito
dc.subjectHuman Immunodeficiency Virusen
dc.subjectlymphocyte activationen
dc.subjectantiretroviral agentsen
dc.subjectCD4 T cellen
dc.subjectB cellen
dc.titleLow CD4(+) T-Cell Levels and B-Cell Apoptosis in Vertically HIV-exposed Noninfected Children and Adolescentsen
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Miami
dc.description.affiliationUniversidade Federal de São Paulo, Res Lab, Div Pediat Infect Dis, Dept Pediat, BR-04039032 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Med, Div Infect Dis, São Paulo, Brazil
dc.description.affiliationUniv Miami, Miller Sch Med, Dept Microbiol & Immunol & Pediat, Miami, FL 33136 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Res Lab, Div Pediat Infect Dis, Dept Pediat, BR-04039032 São Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 04/15316-4
dc.description.sponsorshipIDFAPESP: 04/15317-0
dc.description.sponsorshipIDMiami Fogarty: AITRP5D43TW000017
dc.description.sponsorshipIDMiami Developmental Center for AIDS Research: P30AI073961
dc.description.sourceWeb of Science

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