Effects of topical application of 10,000 IU heparin on patients with perineal dermatitis and second-degree burns treated in a public pediatric hospital

Effects of topical application of 10,000 IU heparin on patients with perineal dermatitis and second-degree burns treated in a public pediatric hospital

Author Ferreira Chacon, Julieta Maria Autor UNIFESP Google Scholar
Mello de Andrea, Maria Lydia Google Scholar
Blanes, Leila Autor UNIFESP Google Scholar
Ferreira, Lydia Masako Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Darcy Vargas Pediat Hosp
Abstract Background: High-molecular-weight sodium heparin (10,000 IU) has been developed based on studies conducted on burn patients; it has anti-inflammatory, antigenic and anticoagulant properties.Objectives: the aim of this paper was to evaluate the effects of topical application of sodium heparin spray on two immunosuppressed patients (a child and a young person) with perineal dermatitis and an immunosuppressed child with second-degree burns.Methods: This is a report of three clinical cases treated in a pediatric hospital. Sodium heparin spray (10,000 IU) was applied at a dose of 4200 IU per percentage of body surface area affected over the hyperemic region. Heparin spray treatment was discontinued after crust formation and wound reepithelialization; essential fatty acid was applied until spontaneous separation of the crust or total wound reepithelialization.Results: Heparin spray had analgesic, angiogenic and anti-inflammatory effects, and did not require secondary wound closure. Pain control was of fundamental importance to the patients; in the three cases, improvement in analgesia was achieved within 24 h of treatment.Conclusion: the topical application of heparin spray in patients with perineal dermatitis or superficial second-degree burns demonstrated good tolerability, resulted in good aesthetic outcomes, and reduced pain. (C) 2010 Tissue Viability Society. Published by Elsevier B.V. All rights reserved.
Keywords Contact dermatitis
Burns
Child
Sodium heparin
Language English
Date 2010-11-01
Published in Journal of Tissue Viability. Oxford: Elsevier B.V., v. 19, n. 4, p. 150-158, 2010.
ISSN 0965-206X (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 150-158
Origin http://dx.doi.org/10.1016/j.jtv.2010.03.003
Access rights Closed access
Type Article
Web of Science ID WOS:000208391800005
URI http://repositorio.unifesp.br/handle/11600/33044

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account