Acute and chronic exercise modulates the expression of MOR opioid receptors in the hippocampal formation of rats

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dc.contributor.author Rodrigues de Oliveira, Monica Silvia
dc.contributor.author Silva Fernandes, Maria Jose da [UNIFESP]
dc.contributor.author Scorza, Fulvio Alexandre [UNIFESP]
dc.contributor.author Persike, Danielle Suzete [UNIFESP]
dc.contributor.author Scorza, Carla Alessandra [UNIFESP]
dc.contributor.author Ponte, Jaqueline Botelho da
dc.contributor.author Albuquerque, Marly de
dc.contributor.author Cavalheiro, Esper Abrao [UNIFESP]
dc.contributor.author Arida, Ricardo Mario [UNIFESP]
dc.date.accessioned 2016-01-24T14:05:35Z
dc.date.available 2016-01-24T14:05:35Z
dc.date.issued 2010-10-30
dc.identifier http://dx.doi.org/10.1016/j.brainresbull.2010.07.009
dc.identifier.citation Brain Research Bulletin. Oxford: Pergamon-Elsevier B.V., v. 83, n. 5, p. 278-283, 2010.
dc.identifier.issn 0361-9230
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/33001
dc.description.abstract Exercise stimulates the release of beta-endorphin and other endogenous opioid peptides that are believed to be responsible for changes in mood perception of pain and also performance Although the vast majority of literature data support the role of physical exercise in increasing beta-endorphin levels indirect measures such as increased endorphin levels in peripheral blood do not reflect opioid levels in the central nervous system the purpose of the present study was to verify whether acute and chronic exercise using both voluntary and forced exercise procedures could modify the expression of mu-opioid receptors (MOR) in rat hippocampal formation Immunoblotting analysis showed significantly enhanced MOR expression in the hippocampal formation in the acute (forced and voluntary) exercise groups when compared to the control group Conversely a significant reduction of MOR expression was noted in the chronic forced and chronic voluntary exercise groups compared to the acute forced and voluntary groups respectively MOR expression was not significantly different in rats trained using both acute or chronic exercise Immunohistochemistry analysis showed a higher number of MOR-positive cells for acute forced and voluntary exercise groups in the CA1 CA3 hilus and dentate gyrus regions compared to the control group Our findings indicate that acute and chronic exercise modulates MOR expression in the hippocampal formation of rats (C) 2010 Elsevier Inc All rights reserved en
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship ClnAPCe
dc.format.extent 278-283
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Brain Research Bulletin
dc.rights Acesso restrito
dc.subject Physical exercise en
dc.subject Opioid en
dc.subject MOR en
dc.subject Receptor en
dc.subject Hippocampal formation en
dc.subject Rats en
dc.title Acute and chronic exercise modulates the expression of MOR opioid receptors in the hippocampal formation of rats en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Univ Mogi das Cruzes NPT
dc.description.affiliation Universidade Federal de São Paulo, Dept Fisiol, BR-04023900 São Paulo, Brazil
dc.description.affiliation Univ Mogi das Cruzes NPT, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Fisiol, BR-04023900 São Paulo, Brazil
dc.identifier.doi 10.1016/j.brainresbull.2010.07.009
dc.description.source Web of Science
dc.identifier.wos WOS:000284514300016



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