Acute and chronic exercise modulates the expression of MOR opioid receptors in the hippocampal formation of rats

Acute and chronic exercise modulates the expression of MOR opioid receptors in the hippocampal formation of rats

Author Rodrigues de Oliveira, Monica Silvia Google Scholar
Silva Fernandes, Maria Jose da Autor UNIFESP Google Scholar
Scorza, Fulvio Alexandre Autor UNIFESP Google Scholar
Persike, Danielle Suzete Autor UNIFESP Google Scholar
Scorza, Carla Alessandra Autor UNIFESP Google Scholar
Ponte, Jaqueline Botelho da Google Scholar
Albuquerque, Marly de Google Scholar
Cavalheiro, Esper Abrao Autor UNIFESP Google Scholar
Arida, Ricardo Mario Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Mogi das Cruzes NPT
Abstract Exercise stimulates the release of beta-endorphin and other endogenous opioid peptides that are believed to be responsible for changes in mood perception of pain and also performance Although the vast majority of literature data support the role of physical exercise in increasing beta-endorphin levels indirect measures such as increased endorphin levels in peripheral blood do not reflect opioid levels in the central nervous system the purpose of the present study was to verify whether acute and chronic exercise using both voluntary and forced exercise procedures could modify the expression of mu-opioid receptors (MOR) in rat hippocampal formation Immunoblotting analysis showed significantly enhanced MOR expression in the hippocampal formation in the acute (forced and voluntary) exercise groups when compared to the control group Conversely a significant reduction of MOR expression was noted in the chronic forced and chronic voluntary exercise groups compared to the acute forced and voluntary groups respectively MOR expression was not significantly different in rats trained using both acute or chronic exercise Immunohistochemistry analysis showed a higher number of MOR-positive cells for acute forced and voluntary exercise groups in the CA1 CA3 hilus and dentate gyrus regions compared to the control group Our findings indicate that acute and chronic exercise modulates MOR expression in the hippocampal formation of rats (C) 2010 Elsevier Inc All rights reserved
Keywords Physical exercise
Opioid
MOR
Receptor
Hippocampal formation
Rats
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
ClnAPCe
Date 2010-10-30
Published in Brain Research Bulletin. Oxford: Pergamon-Elsevier B.V., v. 83, n. 5, p. 278-283, 2010.
ISSN 0361-9230 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 278-283
Origin http://dx.doi.org/10.1016/j.brainresbull.2010.07.009
Access rights Closed access
Type Article
Web of Science ID WOS:000284514300016
URI http://repositorio.unifesp.br/handle/11600/33001

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