Metformin compared with glyburide for the management of gestational diabetes

Metformin compared with glyburide for the management of gestational diabetes

Author Silva, Jean Carl Google Scholar
Pacheco, Carina Google Scholar
Bizato, Juliana Google Scholar
Souza, Barbara Vicente de Google Scholar
Ribeiro, Thais Engel Google Scholar
Bertini, Anna Maria Autor UNIFESP Google Scholar
Institution Univ Reg Joinville UNIVILLE
Universidade Federal de São Paulo (UNIFESP)
Darcy Vargas Matern Hosp Joinville
Dona Helena Hosp Joinville
UNIMED Hosp Ctr Joinville
Abstract Objective: To assess blood glucose control and neonatal outcomes when women with gestational diabetes mellitus (GDM) were treated with metformin or glyburide. Methods: When an appropriate diet was insufficient to control their blood glucose levels, women with GDM were randomized to a glyburide or a metformin treatment group. If the maximum dose was reached, the assessed drug was replaced by insulin. the primary outcome measures analyzed were maternal glucose levels during pregnancy, birth weight, and neonatal glucose levels. Results: the only significant difference in outcome between the 2 treatment drugs was that maternal weight gain during pregnancy was less in the metformin (n=40) than in the glyburide group (n=32) (10.3 kg vs 7.6 kg: P=0.02). No differences were found in treatment failure, mean level of fasting or postprandial plasma glucose, rate of participants with glycated hemoglobin, birth weight, rate of large-for-gestational-age newborns, or newborns with hypoglycemia. Conclusion: the treatment of GDM with metformin or glyburide was found to be equivalent for both women and newborns. (C) 2010 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
Keywords Gestational diabetes mellitus
Language English
Date 2010-10-01
Published in International Journal of Gynecology & Obstetrics. Clare: Elsevier B.V., v. 111, n. 1, p. 37-40, 2010.
ISSN 0020-7292 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 37-40
Access rights Closed access
Type Article
Web of Science ID WOS:000282735100009

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