Worldwide Diversity of Klebsiella pneumoniae That Produces beta-Lactamase bla(KPC-2) Gene
Wisell, Karin T.
Gales, Ana C. [UNIFESP]
Quinn, John P.
Is part ofEmerging Infectious Diseases
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Klebsiella pneumoniae isolates that produce carbapenemases (KPCs) are rapidly disseminating worldwide. To determine their genetic background, we investigated 16 bla(KPC-2)-harboring K. pneumoniae isolates from 5 countries. the isolates were multidrug resistant, possessed the bla(KPC-2) gene, and differed by additional beta-lactamase content. They harbored a naturally chromosome-encoded bla gene (bla(SHV-1) [12.5%], bla(SHV-11) [68.7%], or bla(OKP-A/B) [18.8%]) and several acquired and plasmid-encoded genes (bla(TEM-1) [81.3%], bla(CTX-M-2) [31.3%], bla(CTX-M-12) [12.5%], bla(CTX-M-15) [18.7%], and bla(OXA-9) [37.5%]). the bla(KPC-2) gene was always associated with 1 of the Tn4401 isoforms (a, b, or c). Tn4401 was inserted on different-sized plasmids that belonged to different incompatibility groups. Several bla(KPC)-containing K. pneumoniae clones were found: 9 different pulsotypes with 1 major (sequence type 258) and 7 minor distinct allelic profiles. Different clones harboring different plasmids but having identical genetic structure, Tn4401, could be at the origin of the worldwide spread of this emerging resistance gene.
CitationEmerging Infectious Diseases. Atlanta: Centers Disease Control, v. 16, n. 9, p. 1349-1356, 2010.
SponsorshipInstitut National de la Sante et de la Recherche Medicale, France
Ministere de l'Education Nationale et de la Recherche, Universite Paris XI, Paris
Assistance Publique-Hopitaux de Paris, France
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