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dc.contributor.authorNishi, Erika Emy [UNIFESP]
dc.contributor.authorCampos, Ruy Ribeiro [UNIFESP]
dc.contributor.authorBergamaschi, Cassia Toledo [UNIFESP]
dc.contributor.authorAlmeida, Vitor Rossi de [UNIFESP]
dc.contributor.authorRibeiro, Daniel Araki [UNIFESP]
dc.date.accessioned2016-01-24T14:05:11Z
dc.date.available2016-01-24T14:05:11Z
dc.date.issued2010-07-01
dc.identifierhttp://dx.doi.org/10.1177/0960327109358267
dc.identifier.citationHuman & Experimental Toxicology. London: Sage Publications Ltd, v. 29, n. 7, p. 593-599, 2010.
dc.identifier.issn0960-3271
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32713
dc.description.abstractThe aim of this study was to investigate, through the single-cell gel (comet) assay, whether vitamin C is able to protect against renovascular hypertension-induced genotoxicity in multiple organs. A total of 32 male Wistar rats were divided into four groups: negative control (n = 6); animals treated with vitamin C (n = 6); hypertensive rats (n = 10) and hypertensive rats and treated with vitamin C (n = 10). Hypertension was induced as a result of partial obstruction of the left renal artery by means of a silver clip during 6 weeks. Vitamin C was administered at 150 mg/kg during 7 consecutive days before the end of the experimental period. the results showed that vitamin C was able to protect blood cells against hypertension-induced genotoxicity. Brain, liver and heart cells were also protected by vitamin C following hypertension-induced genotoxic damage. Regarding blood pressure, vitamin C reduced the hypertensive state. in conclusion, our results suggest that vitamin C can prevent hypertension-induced DNA damage in blood, liver, brain and heart cells as well as to normalize the blood pressure of rats.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent593-599
dc.language.isoeng
dc.publisherSage Publications Ltd
dc.relation.ispartofHuman & Experimental Toxicology
dc.rightsAcesso restrito
dc.subjecthypertensionen
dc.subjectvitamin Cen
dc.subjectratsen
dc.subjectDNA damageen
dc.subjectsingle cell gel (comet) assayen
dc.titleVitamin C prevents DNA damage induced by renovascular hypertension in multiple organs of Wistar ratsen
dc.typeArtigo
dc.rights.licensehttp://www.uk.sagepub.com/aboutus/openaccess.htm
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniversidade Federal de São Paulo, UNIFESP, Dept Biosci, Santos, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, UNIFESP, Dept Physiol, Paulista Med Sch,Cardiovasc Div, Santos, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, UNIFESP, Dept Biosci, Santos, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, UNIFESP, Dept Physiol, Paulista Med Sch,Cardiovasc Div, Santos, SP, Brazil
dc.description.sponsorshipIDFAPESP: 07/01228-4
dc.identifier.doi10.1177/0960327109358267
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000278881200012


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