Vitamin C prevents DNA damage induced by renovascular hypertension in multiple organs of Wistar rats

Vitamin C prevents DNA damage induced by renovascular hypertension in multiple organs of Wistar rats

Author Nishi, Erika Emy Autor UNIFESP Google Scholar
Campos, Ruy Ribeiro Autor UNIFESP Google Scholar
Bergamaschi, Cassia Toledo Autor UNIFESP Google Scholar
Almeida, Vitor Rossi de Autor UNIFESP Google Scholar
Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract The aim of this study was to investigate, through the single-cell gel (comet) assay, whether vitamin C is able to protect against renovascular hypertension-induced genotoxicity in multiple organs. A total of 32 male Wistar rats were divided into four groups: negative control (n = 6); animals treated with vitamin C (n = 6); hypertensive rats (n = 10) and hypertensive rats and treated with vitamin C (n = 10). Hypertension was induced as a result of partial obstruction of the left renal artery by means of a silver clip during 6 weeks. Vitamin C was administered at 150 mg/kg during 7 consecutive days before the end of the experimental period. the results showed that vitamin C was able to protect blood cells against hypertension-induced genotoxicity. Brain, liver and heart cells were also protected by vitamin C following hypertension-induced genotoxic damage. Regarding blood pressure, vitamin C reduced the hypertensive state. in conclusion, our results suggest that vitamin C can prevent hypertension-induced DNA damage in blood, liver, brain and heart cells as well as to normalize the blood pressure of rats.
Keywords hypertension
vitamin C
rats
DNA damage
single cell gel (comet) assay
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 07/01228-4
Date 2010-07-01
Published in Human & Experimental Toxicology. London: Sage Publications Ltd, v. 29, n. 7, p. 593-599, 2010.
ISSN 0960-3271 (Sherpa/Romeo, impact factor)
Publisher Sage Publications Ltd
Extent 593-599
Origin http://dx.doi.org/10.1177/0960327109358267
Access rights Closed access
Type Article
Web of Science ID WOS:000278881200012
URI http://repositorio.unifesp.br/handle/11600/32713

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