Assessment of working memory in patients with mesial temporal lobe epilepsy associated with unilateral hippocampal sclerosis
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2010-07-01
Autores
Silva Tudesco, Ivanda de Souza [UNIFESP]
Vaz, Leonardo Jose [UNIFESP]
Silva Mantoan, Marcele Araujo [UNIFESP]
Belzunces, Erich [UNIFESP]
Noffs, Maria Helena [UNIFESP]
Sales Ferreira Caboclo, Luis Otavio [UNIFESP]
Targas Yacubian, Elza Marcia [UNIFESP]
Sakamoto, Americo Ceiki [UNIFESP]
Amodeo Bueno, Orlando Francisco [UNIFESP]
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Objective: the aim of the present study was to investigate whether working memory is impaired in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS), a controversial and largely unexplored matter.Methods: Twenty subjects with left MTLE-HS, 19 with right MTLE-HS, and 21 control right-handed subjects underwent neuropsychological assessment of episodic and semantic memory, executive functions, and specific working memory components.Results: Left and right epileptogenic foci resulted in impairment of verbal and nonverbal episodic memory (verbal memory deficit greater in left MTLE-HS than in right MTLE-HS). in addition, patients with left MTLE-HS were impaired in teaming paired associates, verbal fluency, and Trail Making. No differences were seen in the tests carried out to evaluate the working memory components (except visuospatial short-term memory in right MTLE-HS).Conclusion: in this study we did not detect reliable working memory impairment in patients with MTLE-HS with either a left or right focus in most tasks considered as tests of working memory components. (C) 2010 Elsevier Inc. All rights reserved.
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Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 18, n. 3, p. 223-228, 2010.