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dc.contributor.authorGuimaraes, Carla Aiolfi
dc.contributor.authorMenaa, Farid
dc.contributor.authorMenaa, Bouzid
dc.contributor.authorQuenca-Guillen, Joyce S.
dc.contributor.authorMatos, Jivaldo do Rosario
dc.contributor.authorMercuri, Lucildes Pita [UNIFESP]
dc.contributor.authorBraz, Andre Borges
dc.contributor.authorRossetti, Fabia Cristina
dc.contributor.authorMaria Kedor-Hackmann, Erika Rosa
dc.contributor.authorRocha Miritello Santoro, Maria Ines
dc.identifier.citationThermochimica Acta. Amsterdam: Elsevier B.V., v. 505, n. 1-2, p. 73-78, 2010.
dc.description.abstractIsotretinoin is the drug of choice for the management of severe recalcitrant nodular acne. Nevertheless, some of its physical-chemical properties are still poorly known. Hence, the aim of our study consisted to comparatively evaluate the particle size distribution (PSD) and characterize the thermal behavior of the three encapsulated isotretinoin products in oil suspension (one reference and two generics) commercialized in Brazil. Here, we show that the PSD, estimated by laser diffraction and by polarized light microscopy, differed between the generics and the reference product. However, the thermal behavior of the three products, determined by thermogravimetry (TGA), differential thermal (DTA) analyses and differential scanning calorimetry (DSC), displayed no significant changes and were more thermostable than the isotretinoin standard used as internal control.Thus, our study suggests that PSD analyses in isotretinoin lipid-based formulations should be routinely performed in order to improve their quality and bioavailability. (C) 2010 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.publisherElsevier B.V.
dc.relation.ispartofThermochimica Acta
dc.rightsAcesso restrito
dc.subjectParticle size distributionen
dc.subjectThermal analysisen
dc.subjectQuality controlen
dc.subjectPolarized light microscopyen
dc.subjectLaser diffractionen
dc.titleComparative physical-chemical characterization of encapsulated lipid-based isotretinoin products assessed by particle size distribution and thermal behavior analysesen
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionSch Med Wuerzburg
dc.contributor.institutionFluorotronics Inc
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniv São Paulo, Dept Pharm, Fac Pharmaceut Sci, BR-05508000 São Paulo, Brazil
dc.description.affiliationSch Med Wuerzburg, Dept Dermatol, D-97080 Wurzburg, Germany
dc.description.affiliationFluorotronics Inc, San Diego Technol Incubator, San Diego, CA 92101 USA
dc.description.affiliationUniv São Paulo, Dept Fundamental Chem, Inst Chem, BR-05508000 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Exact & Earth Sci, BR-09972270 Diadema, SP, Brazil
dc.description.affiliationUniv São Paulo, Dept Engn Mines & Oil, Polytech Sch, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Pharmaceut Sci, Fac Pharmaceut Sci Ribeirao Preto, BR-14015120 Ribeirao Preto, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Exact & Earth Sci, BR-09972270 Diadema, SP, Brazil
dc.description.sourceWeb of Science

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