Chagas' disease: an update on immune mechanisms and therapeutic strategies
Boscardin, Silvia Beatriz
Troccoli Torrecilhas, Ana Claudia
Gonzalez Rey, Elena
Tonelli, Renata Rosito [UNIFESP]
Silber, Ariel Mariano
Is part ofJournal of Cellular and Molecular Medicine
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The final decade of the 20th century was marked by an alarming resurgence in infectious diseases caused by tropical parasites belonging to the kinetoplastid protozoan order. Among the pathogenic trypanosomatids, some species are of particular interest due to their medical importance. These species include the agent responsible for Chagas' disease, Trypanosoma cruzi. Approximately 8 to 10 million people are infected in the Americas, and approximately 40 million are at risk. in the present review, we discuss in detail the immune mechanisms elicited during infection by T. cruzi and the effects of chemotherapy in controlling parasite proliferation and on the host immune system.
CitationJournal of Cellular and Molecular Medicine. Malden: Wiley-Blackwell, v. 14, n. 6B, p. 1373-1384, 2010.
SponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Instituto Nacional de Biologia Estrutural e QuImica Medicinal em Doencas Infecciosas (INBEQMeDI)
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