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dc.contributor.authorPiano, Aline de [UNIFESP]
dc.contributor.authorTock, Lian [UNIFESP]
dc.contributor.authorCarnier, June [UNIFESP]
dc.contributor.authorOyama, Lila Missae [UNIFESP]
dc.contributor.authorNascimento, Claudia Maria da Penha Oller do [UNIFESP]
dc.contributor.authorComparoni, Aniella [UNIFESP]
dc.contributor.authorFoschini, Denis [UNIFESP]
dc.contributor.authorSanches, Priscila de Lima [UNIFESP]
dc.contributor.authorErnandes, Regina M. Y. [UNIFESP]
dc.contributor.authorMello, Marco Tulio de [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorDâmaso, Ana Raimunda [UNIFESP]
dc.date.accessioned2016-01-24T13:59:39Z
dc.date.available2016-01-24T13:59:39Z
dc.date.issued2010-05-01
dc.identifierhttps://dx.doi.org/10.1016/j.metabol.2009.09.003
dc.identifier.citationMetabolism-clinical and Experimental. Philadelphia: W B Saunders Co-Elsevier Inc, v. 59, n. 5, p. 613-619, 2010.
dc.identifier.issn0026-0495
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/32516
dc.description.abstractThe complexity pathogenesis in the nonalcoholic fatty liver disease (NAFLD) involves an interplay between adipokines and neuroendocrine regulation of energy balance, including the role of neuropeptide Y (NPY)/agouti-related protein (AgRP) system. the first aim of this study was to assess the effect of long-term interdisciplinary intervention on NAFLD in obese adolescents, and the second objective was to establish the relationship between NPY/AgRP ratio and adiponectinemia. Fifty-five postpuberty obese adolescents were submitted to interdisciplinary intervention. the group was divided between subjects with and without NAFLD (n = 19 and 36, respectively). Blood samples were collected to measure glyccmia, hepatic transaminases, lipid profile, insulin resistance, and sensitivity. Adiponectin, NPY, and AgRP concentrations were measured by enzyme-linked immunosorbent assay. Food intake was measured using 3-day diet records. It was observed at baseline that important clinical parameters including body weight, body mass index, visceral fat, homeostasis model assessment of insulin resistance, quantitative insulin sensitivity check index, triglyccrides, very low-density lipoprotein cholesterol, and hepatic transaminases were more altered in NAFLD patients. After the intervention these parameters, total energy, and macronutrient intake were reduced significantly in both groups. the most important finding was the positive correlation between AgRP and visceral fat in all patients and the negative correlation between NPY/AgRP and adiponectinemia only in NAFLD obese adolescents. the NAFLD patients presented more altered clinical parameters than the non-NAFLD subjects, including the negative correlation between adiponectinemia and NPY/AgRP. These results suggested that NAFLD obese adolescents presented an inflammatory profile that can influence the neuroendocrine regulation of energy balance, suggesting an additional impairment in the weight loss therapy. (C) 2010 Elsevier Inc. All rights reserved.en
dc.description.sponsorshipAFIP
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipCENESP
dc.description.sponsorshipFADA
dc.description.sponsorshipUNIFESP-EPM
dc.format.extent613-619
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofMetabolism-clinical and Experimental
dc.rightsAcesso restrito
dc.titleNegative correlation between neuropeptide Y/agouti-related protein concentration and adiponectinemia in nonalcoholic fatty liver disease obese adolescents submitted to a long-term interdisciplinary therapyen
dc.typeArtigo
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniversidade Federal de São Paulo, Paulista Med Sch, Postgrad Program Nutr, UNIFESP EPM, BR-04020060 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Paulista Med Sch, Assoc Found Incent Physicobiol, UNIFESP EPM, BR-04020060 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Paulista Med Sch, Dept Psychobiol, UNIFESP EPM, BR-04020060 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Paulista Med Sch, Dept Biosci, UNIFESP EPM, BR-04020060 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Paulista Med Sch, Postgrad Program Nutr, UNIFESP EPM, BR-04020060 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Paulista Med Sch, Assoc Found Incent Physicobiol, UNIFESP EPM, BR-04020060 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Paulista Med Sch, Dept Psychobiol, UNIFESP EPM, BR-04020060 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Paulista Med Sch, Dept Biosci, UNIFESP EPM, BR-04020060 São Paulo, Brazil
dc.description.sponsorshipIDFAPESP: 2008/53069-0
dc.description.sponsorshipIDFAPESP: 2006/00684-3
dc.description.sponsorshipIDFAPESP: CEP1D/Sleep 9814303-3 ST
dc.identifier.doi10.1016/j.metabol.2009.09.003
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000277103700001


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