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dc.contributor.authorTristao, Vivian Regina [UNIFESP]
dc.contributor.authorCarvalho, Fernando Felippe de [UNIFESP]
dc.contributor.authorGomes, Cinthia Zanini
dc.contributor.authorMiranda, Adriana Regina
dc.contributor.authorVequi-Suplicy, Cintia C.
dc.contributor.authorLamy, Maria Teresa
dc.contributor.authorSchor, Nestor [UNIFESP]
dc.contributor.authorBellini, Maria Helena [UNIFESP]
dc.identifier.citationJournal of Fluorescence. New York: Springer/plenum Publishers, v. 20, n. 3, p. 665-669, 2010.
dc.description.abstractThe progression to end-stage renal failure is independent of the initial pathogenic mechanism. Metabolic acidosis is a common consequence of chronic renal failure that results from inadequate ammonium excretion and decreased tubular bicarbonate reabsorption. Protoporphyrin IX (PpIX) is the immediate metabolic precursor of the heme molecule. the purpose of this study was to evaluate the levels of erythrocytes protoporphyrin IX at an animal model during progressive renal disease. A total of 36 eight-week-old male Wistar rats were divided into six groups: Normal, 4 and 8 weeks after 5/6 nephrectomy (NX). Renal function was evaluated by creatinine clearance and plasma creatinine levels. the autofluorescence of erythrocytes porphyrin of healthy and NX rats was analyzed using fluorescence spectroscopy. Emission spectra were obtained by exciting the samples at 405 nm. Significant differences between normal and NX rats autofluorescence shape occurred in the 600-700 nm spectral region. A correlation was observed between emission band intensity at 635 nm and progression of renal disease.en
dc.relation.ispartofJournal of Fluorescence
dc.rightsAcesso restrito
dc.subjectChronic renal failureen
dc.titleStudy of Blood Porphyrin Spectral Profile for Diagnosis of Chronic Renal Failureen
dc.contributor.institutionIPEN CNEN SP
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationIPEN CNEN SP, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Fis, BR-01498 São Paulo, Brazil
dc.description.affiliationUNIFESP EPM, Disciplina Nefrol, Dept Med, São Paulo, Brazil
dc.description.affiliationUnifespUNIFESP EPM, Disciplina Nefrol, Dept Med, São Paulo, Brazil
dc.description.sourceWeb of Science

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