B-1 cell participation in T-cell-mediated alloimmune response

B-1 cell participation in T-cell-mediated alloimmune response

Author Nogueira-Martins, Mauro F. Autor UNIFESP Google Scholar
Mariano, Mario Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract B-1 and B cells are important producers of natural antibodies in mice and humans and, therefore, are considered as the first line of defense against pathogens. Because of that, their role in T-cell-mediated immune responses is commonly underrated. However, recent studies have described the participation of B-1 cells in immediate and delayed-type hypersensitivity. the present work assessed the role of B-1 cells in the rejection of allografts in mice, an immune reaction mainly orchestrated by T cells. We have transplanted allogeneic skin and heart to wild-type and B-1-cell-deficient mice, and followed rejection kinetics. Skin graft-infiltrating cells were analyzed by flow cytometry.We observed a delay in rejection kinetics of B-1-cell-deficient mice when compared to wild-type mice. Adoptive transfer of B-1 cells into B-1-cell-deficient mice abrogated this delay. the longer survival observed in the absence of B-I cells correlated with less CD8(+) T cells infiltrating the grafts, as well as with more mast cells. Collectively, our results show the participation of B-1 cells in the allograft rejection process in mice and collaborate to the understanding of B-1 cell biology. (C) 2009 Elsevier GmbH. All rights reserved.
Keywords Alloimmunity
B-1 cells
Graft-infiltrating cells
Mast cells
Transplant rejection
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2010-04-01
Published in Immunobiology. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 215, n. 4, p. 264-274, 2010.
ISSN 0171-2985 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 264-274
Origin http://dx.doi.org/10.1016/j.imbio.2009.05.007
Access rights Closed access
Type Article
Web of Science ID WOS:000276612400002
URI http://repositorio.unifesp.br/handle/11600/32419

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