Surface dental enamel lead levels and antisocial behavior in Brazilian adolescents

Surface dental enamel lead levels and antisocial behavior in Brazilian adolescents

Author Olympio, Kelly P. K. Google Scholar
Oliveira, Pedro V. Google Scholar
Naozuka, Juliana Google Scholar
Cardoso, Maria R. A. Google Scholar
Marques, Antonio F. Google Scholar
Guenther, Wanda M. R. Google Scholar
Bechara, Etelvino J. H. Autor UNIFESP Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Lead poisoning has been reportedly linked to a high risk of learning disabilities, aggression and criminal offenses. To study the association between lead exposure and antisocial/delinquent behavior, a cross-sectional study was conducted with 173 Brazilian youths aged 14-18 and their parents (n=93), living in impoverished neighborhoods of Bauru-SP, with high criminality indices. Self-Reported Delinquency (SRD) and Child Behavior Checklist (CBCL) questionnaires were used to evaluate delinquent/antisocial behavior. Body lead burdens were evaluated in surface dental enamel acid microbiopsies. the dental enamel lead levels (DELL) were quantified by graphite furnace atomic absorption spectrometry (GFAAS) and phosphorus content was measured using inductively coupled plasma optical emission spectrometry (ICP-OES). Logistic regression was used to identify associations between DELL and each scale defined by CBCL and SRD scores. Odd ratios adjusted for familial and social covariates, considering a group of youths exposed to high lead levels (>= 75 percentile), indicated that high DELL is associated with increased risk of exceeding the clinical score for somatic complaints, social problems, rule-breaking behavior and externalizing problems (Cl 95%). High DELL was not found to be associated with elevated SRD scores. in conclusion, our data support the hypothesis that high-level lead exposure can trigger antisocial behavior, which calls for public policies to prevent lead poisoning. (C) 2009 Elsevier Inc. All rights reserved.
Keywords Lead poisoning
Dental enamel biopsy
Antisocial behavior
Juvenile delinquency
5-Aminolevulinic acid
Oxidative stress
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number FAPESP: 01/09641-1
FAPESP: 06/56530-4
CNPq: 303049/2007-3
Date 2010-03-01
Published in Neurotoxicology and Teratology. Oxford: Pergamon-Elsevier B.V., v. 32, n. 2, p. 273-279, 2010.
ISSN 0892-0362 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 273-279
Access rights Closed access
Type Article
Web of Science ID WOS:000276702500021

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