Association of genetic variants in the adiponectin encoding gene (ADIPOQ) with type 2 diabetes in Japanese Brazilians

Association of genetic variants in the adiponectin encoding gene (ADIPOQ) with type 2 diabetes in Japanese Brazilians

Author Vendramini, Marcio F. Google Scholar
Pereira, Alexandre C. Google Scholar
Ferreira, Sandra R. Google Scholar
Kasamatsu, Teresa S. Google Scholar
Moises, Regina S. Autor UNIFESP Google Scholar
Japanese Brazilian Diabet Study Gr Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Aim: the objective of this study is to assess the contribution of ADIPOQ variants to type 2 diabetes in Japanese Brazilians. Methods: We genotyped 200 patients with diabetes mellitus (100 male and 100 female, aged 55.0 years [47.5-64.0 years]) and 200 control subjects with normal glucose tolerant (NGT) (72 male and 128 female, aged 52.0 years [43.5-64.5 years]). Results: Whereas each polymorphism studied (T45G, G276T, and A349G) was not significantly associated with type 2 diabetes mellitus, the haplotype GGA was overrepresented in our diabetic population (9.3% against 3.1% in NGT individuals, P=.0003). Also, this haplotype was associated with decreased levels of adiponectin. We also identified three mutations in exon 3: I164T, R221S, and H241P, but, owing to the low frequencies of them, associations with type 2 diabetes could not be evaluated. the subjects carrying the R221S mutation had plasma adiponectin levels lower than those without the mutation (2.10 mu g/ml [1.35-2.55 mu g/ml] vs. 6.68 mu g/ml [3.90-11.23 mu g/ml], P=.015). Similarly, the I164T mutation carriers had mean plasma adiponectin levels lower than those noncarriers (3.73 mu g/ml [3.10-4.35 mu g/ml] vs. 6.68 mu g/ml [3.90-11.23 mu g/ml]), but this difference was not significant (P=.17). Conclusions: We identified in the ADIPOQ gene a risk haplotype for type 2 diabetes in the Japanese Brazilian population. (C) 2010 Elsevier Inc. All rights reserved.
Keywords Adiponectin
Japanese Brazilian
Single nucleotide polymorphisms
ADIPOQ gene
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2010-03-01
Published in Journal of Diabetes and Its Complications. New York: Elsevier B.V., v. 24, n. 2, p. 115-120, 2010.
ISSN 1056-8727 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 115-120
Origin http://dx.doi.org/10.1016/j.jdiacomp.2009.01.007
Access rights Closed access
Type Article
Web of Science ID WOS:000278171200008
URI http://repositorio.unifesp.br/handle/11600/32335

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