Changes in the Production of IL-10 and TNF-alpha in Skeletal Muscle of Rats with Heart Failure Secondary to Acute Myocardial Infarction

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dc.contributor.author Lopes, Renato Delacio [UNIFESP]
dc.contributor.author Batista Junior, Miguel Luiz
dc.contributor.author Rosa, Jose Cesar
dc.contributor.author Lira, Fabio Santos de [UNIFESP]
dc.contributor.author Martins, Eivor
dc.contributor.author Shimura, Alex Yamashita
dc.contributor.author Brum, Patricia Chakur
dc.contributor.author Lancha, Antonio Herbert
dc.contributor.author Seelaender, Martha C. L.
dc.contributor.author Lopes, Antonio Carlos [UNIFESP]
dc.date.accessioned 2016-01-24T13:59:22Z
dc.date.available 2016-01-24T13:59:22Z
dc.date.issued 2010-03-01
dc.identifier http://dx.doi.org/10.1590/S0066-782X2010000300006
dc.identifier.citation Arquivos Brasileiros de Cardiologia. Rio de Janeiro: Arquivos Brasileiros Cardiologia, v. 94, n. 3, p. 313-320, 2010.
dc.identifier.issn 0066-782X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/32306
dc.description.abstract Background: Recent studies show that the expression of inflammatory mediators, such as cytokines, is an important factor for the development and progression of heart failure (HF), especially in the presence of left ventricular dysfunction. These changes have been demonstrated both in the plasma and heart muscle and, more recently, in skeletal muscle of rats and in patients with HF.Objective: To investigate the production and expression of tumor necrosis factor-alpha (TNF) and interleukin-10 (IL-10) in the soleus and the extensor digitorum longus (EDL) muscles of animals with left ventricular dysfunction after myocardial infarction (MI).Methods: We used male Wistar rats that underwent ligation of the left coronary artery without reperfusion. Four weeks after this procedure, the animals underwent echocardiography and were divided into the following experimental groups: sham operated (sham) and IM. They remained under observation for a further period of 8 weeks.Results: the level of the cytokine TNF-alpha increased by 26.5% (p <0.05), and its gene expression increased 3 times (p <0.07). the level of IL-70 decreased by 38.2% (p <0.05). Both changes occurred only in the soleus muscle, with no change in the EDL. the decrease (36.5%, p <0.05) in the IL-10/TNF-alpha ratio was due to both increased tissue levels of TNF-alpha and decreased tissue levels of IL-10.Conclusion: Our results showed significant changes in the IL-10/TNF-alpha ratio, which may have an additive role in the assessment of deterioration and progression of left ventricular dysfunction post-MI. Furthermore, our study suggests that these changes seem to be related to the muscle fiber type. (Arq Bras Cardiol 2010; 94(3):293-300) en
dc.format.extent 313-320
dc.language.iso por
dc.publisher Arquivos Brasileiros Cardiologia
dc.relation.ispartof Arquivos Brasileiros de Cardiologia
dc.rights Acesso aberto
dc.subject Ventricular dysfunction, left en
dc.subject muscle, skeletal en
dc.subject cytokines en
dc.subject inflammation en
dc.title Changes in the Production of IL-10 and TNF-alpha in Skeletal Muscle of Rats with Heart Failure Secondary to Acute Myocardial Infarction en
dc.type Artigo
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Univ Mogi das Cruzes
dc.contributor.institution Duke Clin Res Inst
dc.description.affiliation Univ São Paulo, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliation Univ Mogi das Cruzes, Mogi Das Cruzes, Brazil
dc.description.affiliation Duke Clin Res Inst, Durham, NC USA
dc.description.affiliationUnifesp Universidade Federal de São Paulo, São Paulo, Brazil
dc.identifier.file S0066-782X2010000300006-en.pdf
dc.identifier.file S0066-782X2010000300006-pt.pdf
dc.identifier.scielo S0066-782X2010000300006
dc.identifier.doi 10.1590/S0066-782X2010000300006
dc.description.source Web of Science
dc.identifier.wos WOS:000276239200006



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