Monocyte transplantation for neural and cardiovascular ischemia repair
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Data
2010-03-01
Autores
Sanberg, Paul R.
Park, Dong-Hyuk
Kuzmin-Nichols, Nicole
Cruz, Eduardo
Hossne, Nelson Americo [UNIFESP]
Buffolo, Enio [UNIFESP]
Willing, Alison E.
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Neovascularization is an integral process of inflammatory reactions and subsequent repair cascades in tissue injury. Monocytes/macrophages play a key role in the inflammatory process including angiogenesis as well as the defence mechanisms by exerting microbicidal and immunomodulatory activity. Current studies have demonstrated that recruited monocytes/macrophages aid in regulating angiogenesis in ischemic tissue, tumours and chronic inflammation. in terms of neovascularization followed by tissue regeneration, monocytes/macrophages should be highly attractive for cell-based therapy compared to any other stem cells due to their considerable advantages: non-oncogenic, non-teratogenic, multiple secretary functions including pro-angiogenic and growth factors, straightforward cell harvesting procedure and non-existent ethical controversy. in addition to adult origins such as bone marrow or peripheral blood, umbilical cord blood (UCB) can be a potential source for autologous or allogeneic monocytes/macrophages. Especially, UCB monocytes should be considered as the first candidate owing to their feasibility, low immune rejection and multiple characteristic advantages such as their anti-inflammatory properties by virtue of their unique immune and inflammatory immaturity, and their proangiogenic ability. in this review, we present general characteristics and potential of monocytes/macrophages for cell-based therapy, especially focusing on neovascularization and UCB-derived monocytes.
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Journal of Cellular and Molecular Medicine. Hoboken: Wiley-Blackwell, v. 14, n. 3, p. 553-563, 2010.