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dc.contributor.authorSanberg, Paul R.
dc.contributor.authorPark, Dong-Hyuk
dc.contributor.authorKuzmin-Nichols, Nicole
dc.contributor.authorCruz, Eduardo
dc.contributor.authorHossne, Nelson Americo [UNIFESP]
dc.contributor.authorBuffolo, Enio [UNIFESP]
dc.contributor.authorWilling, Alison E.
dc.date.accessioned2016-01-24T13:59:21Z
dc.date.available2016-01-24T13:59:21Z
dc.date.issued2010-03-01
dc.identifierhttp://dx.doi.org/10.1111/j.1582-4934.2009.00903.x
dc.identifier.citationJournal of Cellular and Molecular Medicine. Hoboken: Wiley-Blackwell, v. 14, n. 3, p. 553-563, 2010.
dc.identifier.issn1582-1838
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/32294
dc.description.abstractNeovascularization is an integral process of inflammatory reactions and subsequent repair cascades in tissue injury. Monocytes/macrophages play a key role in the inflammatory process including angiogenesis as well as the defence mechanisms by exerting microbicidal and immunomodulatory activity. Current studies have demonstrated that recruited monocytes/macrophages aid in regulating angiogenesis in ischemic tissue, tumours and chronic inflammation. in terms of neovascularization followed by tissue regeneration, monocytes/macrophages should be highly attractive for cell-based therapy compared to any other stem cells due to their considerable advantages: non-oncogenic, non-teratogenic, multiple secretary functions including pro-angiogenic and growth factors, straightforward cell harvesting procedure and non-existent ethical controversy. in addition to adult origins such as bone marrow or peripheral blood, umbilical cord blood (UCB) can be a potential source for autologous or allogeneic monocytes/macrophages. Especially, UCB monocytes should be considered as the first candidate owing to their feasibility, low immune rejection and multiple characteristic advantages such as their anti-inflammatory properties by virtue of their unique immune and inflammatory immaturity, and their proangiogenic ability. in this review, we present general characteristics and potential of monocytes/macrophages for cell-based therapy, especially focusing on neovascularization and UCB-derived monocytes.en
dc.format.extent553-563
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Cellular and Molecular Medicine
dc.rightsAcesso aberto
dc.subjectischemiaen
dc.subjectinflammationen
dc.subjectangiogenesis/arteriogenesisen
dc.subjectmonocyte/macrophageen
dc.subjectumbilical cord blooden
dc.subjectbone marrowen
dc.subjectperipheral blooden
dc.subjecttransplantationen
dc.subjectstem cellsen
dc.titleMonocyte transplantation for neural and cardiovascular ischemia repairen
dc.typeArtigo
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institutionUniv S Florida
dc.contributor.institutionSaneron CCEL Therapeut INC
dc.contributor.institutionPolo Biotecnol Rio Janeiro
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUniv S Florida, Dept Neurosurg & Brain Repair, Ctr Excellence Aging & Brain Repair, Coll Med, Tampa, FL 33612 USA
dc.description.affiliationUniv S Florida, Off Res & Innovat, Tampa, FL 33612 USA
dc.description.affiliationSaneron CCEL Therapeut INC, Tampa, FL USA
dc.description.affiliationPolo Biotecnol Rio Janeiro, BioRio, Cryopraxis & Silvestre Lab, Rio de Janeiro, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Cardiovasc Surg, Paulista Sch Med, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Cardiovasc Surg, Paulista Sch Med, São Paulo, Brazil
dc.identifier.fileWOS000276950100007.pdf
dc.identifier.doi10.1111/j.1582-4934.2009.00903.x
dc.description.sourceWeb of Science
dc.identifier.wosWOS:000276950100007


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