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dc.contributor.authorBrandao, Sergio A. [UNIFESP]
dc.contributor.authorIzar, Maria C. [UNIFESP]
dc.contributor.authorFischer, Simone M. [UNIFESP]
dc.contributor.authorSantos, Andreza O. [UNIFESP]
dc.contributor.authorMonteiro, Carlos M. [UNIFESP]
dc.contributor.authorPovoa, Rui M. [UNIFESP]
dc.contributor.authorHelfenstein, Tatiana [UNIFESP]
dc.contributor.authorCarvalho, Antonio C. [UNIFESP]
dc.contributor.authorMonteiro, Andrea M.
dc.contributor.authorRamos, Eduardo
dc.contributor.authorGidlund, Magnus
dc.contributor.authorFigueiredo Neto, Antonio M.
dc.contributor.authorFonseca, Francisco A. [UNIFESP]
dc.identifier.citationAmerican Journal of Hypertension. New York: Nature Publishing Group, v. 23, n. 2, p. 208-214, 2010.
dc.description.abstractBACKGROUNDOxidized lipoproteins and antioxidized low-density lipoprotein (anti-oxLDL) antibodies (Abs) have been detected in plasma in response to blood pressure (BP) elevation, suggesting the participation of the adaptive immune system. Therefore, treatment of hypertension may act on the immune response by decreasing oxidation stimuli. However, this issue has not been addressed. Thus, we have here analyzed anti-oxLDL Abs in untreated (naive) hypertensive patients shortly after initiation of anti hypertensive therapeutic regimens.METHODSTiters of anti-oxLDL Abs were measured in subjects with recently diagnosed hypertension on stage 1 (n = 94), in primary prevention of coronary disease, with no other risk factors, and naive of anti hypertensive medication at entry. Subjects were randomly assigned to receive perindopril, hydrochlorothiazide (HCTZ), or indapamide (INDA) for 12 weeks, with additional perindopril if necessary to achieve BP control. Abs against copper-oxidized LDL were measured by enzyme-linked immunosorbent assay.RESULTSTwelve-week antihypertensive treatment reduced both office-based and 24-h ambulatory BP measurements (P < 0.0005). the decrease in BP was accompanied by reduction in thiobarbituric acid-reactive substances (TBARS) (P < 0.05), increase in anti-oxLDL Ab titers (P < 0.005), and improvement in flow-mediated dilation (FMD) (P < 0.0005), independently of treatment. Although BP was reduced, we observed favorable changes in anti-oxLDL titers and FMD.CONCLUSIONSWe observed that anti-oxLDL Ab titers increase after antihypertensive therapy in primary prevention when achieving BP targets. Our results are in agreement with the concept that propensity to oxidation is increased by essential hypertension and anti-oxLDL Abs may be protective and potential biomarkers for the follow-up of hypertension treatment.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipThe National Institute of Science and Technology of Complex Fluids (INCT-FCx)
dc.description.sponsorshipThe National Institute of Science and Technology-Nanomaterials for Integrated Markers (INCT-IINAMI)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.publisherNature Publishing Group
dc.relation.ispartofAmerican Journal of Hypertension
dc.rightsAcesso restrito
dc.subjectangiotensin-converting enzyme inhibitoren
dc.subjectblood pressureen
dc.subjectoxidized LDLen
dc.titleEarly Increase in Autoantibodies Against Human Oxidized Low-Density Lipoprotein in Hypertensive Patients After Blood Pressure Controlen
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.description.affiliationUniversidade Federal de São Paulo, Div Cardiol, Dept Med, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Immunol, Inst Biomed Sci, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Dept Complex Fluids, Inst Phys, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Cardiol, Dept Med, São Paulo, Brazil
dc.description.sourceWeb of Science

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